Parallel manipulation of bifunctional DNA molecules on structured surfaces using kinesin-driven microtubules
Publikation: Beitrag in Fachzeitschrift › Forschungsartikel › Beigetragen › Begutachtung
Beitragende
Abstract
We have developed a technique to manipulate bifunctional DNA molecules: One end in thiolated to bind to a patterned gold surface and the other end is biotinylated to bind to a microtubule gliding over a kinesin-coated surface. We found that DNA molecules can be stretched and overstretched between the gold pads and the motile microtubules, and that they can form dynamic networks. This serves as a proof-of-principle that biological machineries can be used in vitro to accomplish the parallel formation of structured DNA templates that will have applications in biophysics and nanoelectronics.
Details
Originalsprache | Englisch |
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Seiten (von - bis) | 1090-1098 |
Seitenumfang | 9 |
Fachzeitschrift | Small |
Jahrgang | 2 |
Ausgabenummer | 8-9 |
Publikationsstatus | Veröffentlicht - Aug. 2006 |
Peer-Review-Status | Ja |
Externe IDs
PubMed | 17193173 |
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ORCID | /0000-0002-0750-8515/work/142235585 |
Schlagworte
Forschungsprofillinien der TU Dresden
ASJC Scopus Sachgebiete
Schlagwörter
- DNA, Kinesin, Microtubules, Nanomanipulation