Out with the old, in with the new: senescence in development

Publikation: Beitrag in FachzeitschriftÜbersichtsartikel (Review)EingeladenBegutachtung

Abstract

Cellular senescence is a ubiquitous stress response that restricts the proliferative capacity of cells. During ageing, senescent cells accumulate in various tissues leading to a number of age-related pathologies and physiological decline. Previously thought to be a process restricted to adult organisms, cellular senescence has been recently demonstrated to occur during embryonic development of animals ranging from fish to mammals. Together, these studies suggest that developmentally programmed senescence is a transient but intrinsic biological process that contributes to the remodelling of developing structures by promoting immune-mediated cell clearance of particular cell populations or modifying the tissue microenvironment. These observations have important implications for the evolutionary origins of this essential, yet paradoxical mechanism.

Details

OriginalspracheEnglisch
Seiten (von - bis)74-80
Seitenumfang7
FachzeitschriftCurrent opinion in cell biology
Jahrgang55
PublikationsstatusVeröffentlicht - Dez. 2018
Peer-Review-StatusJa

Externe IDs

Scopus 85049652084

Schlagworte

Schlagwörter

  • Aging/physiology, Animals, Biological Evolution, Cellular Senescence, Embryonic Development, Humans, Stress, Physiological