Optimized Whole-Body PET MRI Sequence Workflow in Pediatric Hodgkin Lymphoma Patients

Publikation: Beitrag in FachzeitschriftForschungsartikelBeigetragenBegutachtung

Beitragende

  • Thomas W. Georgi - , Universität Leipzig (Autor:in)
  • Dietrich Stoevesandt - , Martin-Luther-Universität Halle-Wittenberg (Autor:in)
  • Lars Kurch - , Universität Leipzig (Autor:in)
  • Jörg M. Bartelt - , Martin-Luther-Universität Halle-Wittenberg (Autor:in)
  • Dirk Hasenclever - , Universität Leipzig (Autor:in)
  • Helmut Dittmann - , Eberhard Karls Universität Tübingen (Autor:in)
  • Jiri Ferda - , Karlsuniversität Prag (Autor:in)
  • Peter Francis - , Royal Children's Hospital Melbourne (Autor:in)
  • Christiane Franzius - , Center for Nuclear Medicine and PET/CT (Autor:in)
  • Christian Furth - , Charité – Universitätsmedizin Berlin (Autor:in)
  • Daniel Gräfe - , Universität Leipzig (Autor:in)
  • Alexander Gussew - , Martin-Luther-Universität Halle-Wittenberg (Autor:in)
  • Martin Hüllner - , Universität Zürich (Autor:in)
  • Leon J. Menezes - , University College London Hospitals NHS Foundation Trust (Autor:in)
  • Mona Mustafa - , Technische Universität München (Autor:in)
  • Lars Stegger - , Westfälische Wilhelms-Universität Münster (Autor:in)
  • Lale Umutlu - , Universität Duisburg-Essen (Autor:in)
  • Klaus Zöphel - , Klinik und Poliklinik für Nuklearmedizin (Autor:in)
  • Pietro Zucchetta - , Azienda Ospedaliera di Padova (Autor:in)
  • Dieter Körholz - , Justus-Liebig-Universität Gießen (Autor:in)
  • Osama Sabri - , Universität Leipzig (Autor:in)
  • Christine Mauz-Körholz - , Justus-Liebig-Universität Gießen, Martin-Luther-Universität Halle-Wittenberg (Autor:in)
  • Regine Kluge - , Universität Leipzig (Autor:in)

Abstract

18F-FDG PET/MRI might be the diagnostic method of choice for Hodgkin lymphoma patients, as it combines significantmetabolic information fromPET with excellent soft-tissue contrast fromMRI and avoids radiation exposure from CT. However, a major issue is longer examination times than for PET/CT, especially for younger children needing anesthesia. Thus, a targeted selection of suitable whole-body MRI sequences is important to optimize the PET/MRI workflow. Methods: The initial PET/MRI scans of 84 EuroNet-PHL-C2 study patients from 13 international PET centers were evaluated. In each available MRI sequence, 5 PET-positive lymph nodes were assessed. If extranodal involvement occurred, 2 splenic lesions, 2 skeletal lesions, and 2 lung lesions were also assessed. A detection rate was calculated dividing the number of visible, anatomically assignable, and measurable lesions in the respectiveMRI sequence by the total number of lesions. Results: Relaxation time-weighted (T2w) transverse sequences with fat saturation (fs) yielded the best result, with detection rates of 95% for nodal lesions, 62% for splenic lesions, 94% for skeletal lesions, and 83% for lung lesions, followed by T2w transverse sequences without fs (86%, 49%, 16%, and 59%, respectively) and longitudinal relaxation time- weighted contrast-enhanced transverse sequences with fs (74%, 35%, 57%, and 55%, respectively). Conclusion: T2w transverse sequences with fs yielded the highest detection rates and are well suited for accurate whole-body PET/MRI in lymphoma patients. There is no evidence to recommend the use of contrast agents.

Details

OriginalspracheEnglisch
Seiten (von - bis)96-101
Seitenumfang6
FachzeitschriftJournal of Nuclear Medicine
Jahrgang64
Ausgabenummer1
PublikationsstatusVeröffentlicht - Jan. 2023
Peer-Review-StatusJa
Extern publiziertJa

Externe IDs

PubMed 35835583

Schlagworte

Schlagwörter

  • Hodgkin lymphoma, MRI sequences, PET/MRI, wholebody imaging, Bone Diseases, Humans, Whole Body Imaging/methods, Workflow, Magnetic Resonance Imaging/methods, Hodgkin Disease/diagnostic imaging, Positron Emission Tomography Computed Tomography, Fluorodeoxyglucose F18, Diffusion Magnetic Resonance Imaging/methods, Neoplasm Staging, Radiopharmaceuticals, Child, Positron-Emission Tomography/methods

Bibliotheksschlagworte