On the mechanical stability of polymeric microcontainers functionalized with nanoparticles

Publikation: Beitrag in FachzeitschriftForschungsartikelBeigetragenBegutachtung

Beitragende

  • Matthieu F. Bédard - , Max Planck Institute of Colloids and Interfaces, Queen Mary University of London (Autor:in)
  • Almudena Munoz-Javier - , Philipps-Universität Marburg (Autor:in)
  • Renate Mueller - , Max Planck Institute of Colloids and Interfaces (Autor:in)
  • Pablo Del Pino - , Philipps-Universität Marburg (Autor:in)
  • Andreas Fery - , Universität Bayreuth (Autor:in)
  • Wolfgang J. Parak - , Philipps-Universität Marburg (Autor:in)
  • Andre G. Skirtach - , Max Planck Institute of Colloids and Interfaces (Autor:in)
  • Gleb B. Sukhorukov - , Queen Mary University of London (Autor:in)

Abstract

We present key factors that influence the mechanical stability of polyelectrolyte/nanoparticle composite microcontainers and their encapsulation behavior by thermal shrinkage. Poly(diallyldimethylammonium chloride) (PDADMAC), poly(styrenesulfonate) (PSS) microshells and citrate-stabilized gold nanoparticles are used. The presence of nanoparticles in the microshell renders the encapsulation process by heat-shrinking more difficult. The encapsulation efficiency is found to decrease as the concentration of material to be encapsulated increases. Increasing nanoparticle content in the microshell or the concentration of dextran increases the likelihood of getting fused and damaged capsules during encapsulation. On the other hand, mechanical studies show that doping microshells with gold nanoparticles significantly increases their stiffness and resistance to deformation. Internalization of capsules by cells supports that the incorporation of metal nanoparticles makes the shells more resistant to deformation. This work provides information of significant interest for the potential biomedical applications of polymeric microshells such as intracellular storage and delivery.

Details

OriginalspracheEnglisch
Seiten (von - bis)148-155
Seitenumfang8
FachzeitschriftSoft matter
Jahrgang5
Ausgabenummer1
PublikationsstatusVeröffentlicht - 2009
Peer-Review-StatusJa
Extern publiziertJa

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