In this paper, we discuss novel approaches for organic light-emitting diode (OLED) lighting application. In particular, we discuss OLED deposited by vacuum deposition on flexible substrates such as plastic and metal foils. We discuss the specific challenges of OLED design for such substrates, in particular when top-emitting structures are required. Furthermore, we discuss a novel vacuum roll-to-roll tool which is capable of depositing oligomer OLED with high efficiency.