Novel Application of Polymer Networks Carrying Tertiary Amines as a Catalyst Inside Microflow Reactors Used for Knoevenagel Reactions

Publikation: Beitrag in FachzeitschriftForschungsartikelBeigetragenBegutachtung



A novel application is described for utilizing hydrogel dots as organocatalyst carriers inside microfluidic reactors. Tertiary amines were covalently immobilized in the hydrogel dots. Due to the diffusion of reactants within the swollen hydrogel dots, the accessible amount of catalysts inside a microfluidic reactor chamber can be increased compared to the accessible amount of surface‐bound catalysts. To perform fast Knoevenagel reactions, important flow parameters had to be validated to optimize the reactor performance while keeping the dimensions of the reactor chamber constant; e.g. the height of the hydrogel dots had to be adjusted to the invariable dimensions of the reactor chamber, or an adjustment of organocatalysts in the hydrogel dots had to be validated to achieve the highest conversion rate during a certain residence time. To characterize the conversion, nuclear magnetic resonance (NMR) and UV/Vis …


Seiten (von - bis)5765-5774
FachzeitschriftEuropean journal of organic chemistry: EurJOC
PublikationsstatusVeröffentlicht - 2020

Externe IDs

Scopus 85090086528
ORCID /0000-0002-8588-9755/work/142246752