New PTFE-polyamide compounds produced by reactive extrusion show very good material and tribological properties combined with an excellent wear resistance. The basis of these properties is the formation of chemical bonds between PTFE and PA by transamidation in a melt modification reaction. The effective processing and the material properties of PA are combined with the excellent anti-friction properties of PTFE in this innovative material. Test specimen of PA and PA-PTFE obtained by two component injection moulding process show very high interfacial adhesion. The processability of this material on polymer processing equipment and the use of available materials favours the commercialisation of these new PTFE polyamide compounds.