Neuromodulation of associative and organizational plasticity across the life span: Empirical evidence and neurocomputational modeling
Publikation: Beitrag in Fachzeitschrift › Übersichtsartikel (Review) › Beigetragen › Begutachtung
Beitragende
Abstract
Developmental plasticity is the key mechanism that allows humans and other organisms to modify and adapt to contextual and experiential influences. Thus, reciprocal co-constructive interactions between behavioral and neuronal plasticity play important roles in regulating neurobehavioral development across the life span. This review focuses on behavioral and neuronal evidence of lifespan differences in associative memory plasticity and plasticity of the functional organization of cognitive and cortical processes, as well as the role of the dopaminergic system in modulating such plasticity. Special attention is given to neurocomputational models that help exploring lifespan differences in neuromodulation of neuronal and behavioral plasticity. Simulation results from these models suggest that lifespan changes in the efficacy of neuromodulatory mechanisms may shape associative memory plasticity and the functional organization of neurocognitive processes by affecting the fidelity of neuronal signal transmission, which has consequences for the distinctiveness of neurocognitive representations and the efficacy of distributed neural coding.
Details
Originalsprache | Englisch |
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Seiten (von - bis) | 775-790 |
Seitenumfang | 16 |
Fachzeitschrift | Neuroscience and biobehavioral reviews |
Jahrgang | 30 |
Ausgabenummer | 6 |
Publikationsstatus | Veröffentlicht - 2006 |
Peer-Review-Status | Ja |
Extern publiziert | Ja |
Externe IDs
PubMed | 16930705 |
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ORCID | /0000-0001-8409-5390/work/142254957 |
Schlagworte
ASJC Scopus Sachgebiete
Schlagwörter
- Memory plasticity, Neural networks, Neural plasticity, Neuroconstructivism, Neuromodulation, Signal-to-noise