Neurobiological and behavioral mechanisms of circadian rhythm disruption in bipolar disorder: A critical multi-disciplinary literature review and agenda for future research from the ISBD task force on chronobiology

Publikation: Beitrag in FachzeitschriftÜbersichtsartikel (Review)BeigetragenBegutachtung

Beitragende

  • Michael J. McCarthy - , University of California at San Diego, Department of Veterans Affairs (Autor:in)
  • John F. Gottlieb - , Northwestern University (Autor:in)
  • Robert Gonzalez - , Pennsylvania State University (Autor:in)
  • Colleen A. McClung - , University of Pittsburgh (Autor:in)
  • Lauren B. Alloy - , Temple University (Autor:in)
  • Sean Cain - , Monash University (Autor:in)
  • Davide Dulcis - , University of California at San Diego (Autor:in)
  • Bruno Etain - , Université Paris Cité (Autor:in)
  • Benicio N. Frey - , McMaster University (Autor:in)
  • Corrado Garbazza - , Universität Basel (Autor:in)
  • Kyle D. Ketchesin - , University of Pittsburgh (Autor:in)
  • Dominic Landgraf - , Ludwig-Maximilians-Universität München (LMU) (Autor:in)
  • Heon Jeong Lee - , Korea University (Autor:in)
  • Cynthia Marie-Claire - , Université Paris Cité (Autor:in)
  • Robin Nusslock - , Northwestern University (Autor:in)
  • Alessandra Porcu - , University of California at San Diego (Autor:in)
  • Richard Porter - , University of Otago (Autor:in)
  • Philipp Ritter - , Klinik und Poliklinik für Psychiatrie und Psychotherapie, Clinic for Psychiatry and Psychotherapy, Universitätsklinikum Carl Gustav Carus Dresden (Autor:in)
  • Jan Scott - , Newcastle University (Autor:in)
  • Daniel Smith - , University of Edinburgh (Autor:in)
  • Holly A. Swartz - , University of Pittsburgh (Autor:in)
  • Greg Murray - , Swinburne University of Technology (Autor:in)

Abstract

Aim: Symptoms of bipolar disorder (BD) include changes in mood, activity, energy, sleep, and appetite. Since many of these processes are regulated by circadian function, circadian rhythm disturbance has been examined as a biological feature underlying BD. The International Society for Bipolar Disorders Chronobiology Task Force (CTF) was commissioned to review evidence for neurobiological and behavioral mechanisms pertinent to BD. Method: Drawing upon expertise in animal models, biomarkers, physiology, and behavior, CTF analyzed the relevant cross-disciplinary literature to precisely frame the discussion around circadian rhythm disruption in BD, highlight key findings, and for the first time integrate findings across levels of analysis to develop an internally consistent, coherent theoretical framework. Results: Evidence from multiple sources implicates the circadian system in mood regulation, with corresponding associations with BD diagnoses and mood-related traits reported across genetic, cellular, physiological, and behavioral domains. However, circadian disruption does not appear to be specific to BD and is present across a variety of high-risk, prodromal, and syndromic psychiatric disorders. Substantial variability and ambiguity among the definitions, concepts and assumptions underlying the research have limited replication and the emergence of consensus findings. Conclusions: Future research in circadian rhythms and its role in BD is warranted. Well-powered studies that carefully define associations between BD-related and chronobiologically-related constructs, and integrate across levels of analysis will be most illuminating.

Details

OriginalspracheEnglisch
Seiten (von - bis)232-263
Seitenumfang32
FachzeitschriftBipolar disorders
Jahrgang24
Ausgabenummer3
PublikationsstatusVeröffentlicht - Mai 2022
Peer-Review-StatusJa

Externe IDs

PubMed 34850507
ORCID /0000-0003-4286-5830/work/149796269

Schlagworte

Ziele für nachhaltige Entwicklung

Schlagwörter

  • actigraphy, animal models, biomarker, chronobiology, circadian, clock gene, levels of analysis, light, lithium, sleep