Neural basis of reward anticipation and its genetic determinants
Publikation: Beitrag in Fachzeitschrift › Forschungsartikel › Beigetragen › Begutachtung
Beitragende
- King's College London (KCL)
- University of Texas Southwestern Medical Center
- Fudan University
- Universität Heidelberg
- Trinity College Dublin
- University of Montreal
- Commissariat à l’énergie atomique et aux énergies alternatives (CEA)
- University of Vermont
- University of Nottingham
- Physikalisch-Technische Bundesanstalt
- McGill University
- INSERM - Institut national de la santé et de la recherche médicale
- University of Toronto
- Centre Universitaire de Sante McGill
- University of California at Berkeley
- University of Cambridge
- Friedrich-Alexander-Universität Erlangen-Nürnberg
- University of Warwick
- Universitätsklinikum Hamburg-Eppendorf (UKE)
- Universität Hamburg
Abstract
Dysfunctional reward processing is implicated in various mental disorders, including attention deficit hyperactivity disorder (ADHD) and addictions. Such impairments might involve different components of the reward process, including brain activity during reward anticipation. We examined brain nodes engaged by reward anticipation in 1,544 adolescents and identified a network containing a core striatal node and cortical nodes facilitating outcome prediction and response preparation. Distinct nodes and functional connections were preferentially associated with either adolescent hyperactivity or alcohol consumption, thus conveying specificity of reward processing to clinically relevant behavior. We observed associations between the striatal node, hyperactivity, and the vacuolar protein sorting-associated protein 4A (VPS4A) gene in humans, and the causal role of Vps4 for hyperactivity was validated in Drosophila. Our data provide a neurobehavioral model explaining the heterogeneity of rewardrelated behaviors and generate a hypothesis accounting for their enduring nature.
Details
Originalsprache | Englisch |
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Seiten (von - bis) | 3879-3884 |
Seitenumfang | 6 |
Fachzeitschrift | Proceedings of the National Academy of Sciences of the United States of America |
Jahrgang | 113 |
Ausgabenummer | 14 |
Publikationsstatus | Veröffentlicht - 5 Apr. 2016 |
Peer-Review-Status | Ja |
Externe IDs
PubMed | 27001827 |
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ORCID | /0000-0001-5398-5569/work/161890795 |
Schlagworte
ASJC Scopus Sachgebiete
Schlagwörter
- Dopamine receptor, FMRI, GWAS, Neural network, VPS4A