Myosin heavy chain mRNA isoforms in masseter muscle before and after orthognathic surgery

Publikation: Beitrag in FachzeitschriftForschungsartikelBeigetragenBegutachtung

Beitragende

  • Winfried Harzer - , Poliklinik für Kieferorthopädie (Autor:in)
  • Margret Worm - , Poliklinik für Kieferorthopädie (Autor:in)
  • Tomasz Gedrange - , Klinik und Poliklinik für Mund-, Kiefer- und Gesichtschirurgie, Universitätsklinikum Carl Gustav Carus Dresden (Autor:in)
  • Matthias Schneider - , Universitätsklinikum Carl Gustav Carus Dresden, Klinik und Poliklinik für Mund-, Kiefer- und Gesichtschirurgie (Autor:in)
  • Peter Wolf - , Poliklinik für Kieferorthopädie (Autor:in)

Abstract

Objectives: Orthognathic surgery leads to changed jaw position and force vector of mastication to which the muscles must adapt. The aim of the present study was to determine the relative expression of myosin heavy chain (MyHC) messenger RNA (mRNA) isoforms in different types of human masseter muscle fiber under consideration of change in the number of occlusal contacts before and 6 months after surgery. Study design: Muscle biopsies were taken from the anterior and posterior parts of both sides in 30 patients with prognathic and retrognathic mandibles. Specific mRNA MyHC analysis was made by real-time polymerase chain reaction to quantify the isoforms I, IIa, and IId/x. Results: There was a shift in the relative content from type I (46% before, 37% after) to type IIa (29% before, 42% after). This shift correlates with number of teeth in occlusion. Conclusions: Correlation between isoform shift and number of teeth in occlusion indicates higher mastication force which stabalizes the treatment result.

Details

OriginalspracheEnglisch
Seiten (von - bis)486-490
Seitenumfang5
FachzeitschriftOral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology
Jahrgang104
Ausgabenummer4
PublikationsstatusVeröffentlicht - Okt. 2007
Peer-Review-StatusJa

Externe IDs

PubMed 17507262