Molecular interactions between the urokinase receptor and integrins in the vasculature

Publikation: Beitrag in FachzeitschriftÜbersichtsartikel (Review)BeigetragenBegutachtung

Beitragende

  • A. E. May - , Kerckhoff Klinik, Technische Universität München (Autor:in)
  • S. M. Kanse - , Kerckhoff Klinik, Technische Universität München (Autor:in)
  • T. Chavakis - , Kerckhoff Klinik, Technische Universität München (Autor:in)
  • K. T. Preissner - , Kerckhoff Klinik, Technische Universität München (Autor:in)

Abstract

Cell-cell and cell-ECM interactions are key events in morphogenic processes during developmental and reproductive phases, in immune defense, wound healing and tissue repair, or hemostasis. Their dysregulation plays a major role in the pathophysiology of cardiovascular diseases (atherosclerosis, restenosis, thrombosis) or angiogenesis-driven tumor progression. Protease cascades such as the plasminogen activation system are linked to cell adhesion and migration. The urokinase-type plasminogen activator (uPA) as well as its receptor (uPAR) has been found in a complex with β1-, β2-, and β3-integrins, thereby allowing mutual interactions and regulatory processes between cell adhesion and proteolysis to occur. Moreover, both uPAR and PAI-1 are capable of binding to vitronectin, an adhesive extracellular matrix protein, that serves as ligand for vascular integrins in an RGD-dependent manner. This short review will focus on the molecular and functional interactions between the uPAR system and vascular integrins and discuss consequences for vascular cell functions.

Details

OriginalspracheEnglisch
Seiten (von - bis)205-210
Seitenumfang6
FachzeitschriftFibrinolysis & proteolysis
Jahrgang12
Ausgabenummer4
PublikationsstatusVeröffentlicht - 1998
Peer-Review-StatusJa
Extern publiziertJa

Schlagworte

ASJC Scopus Sachgebiete