Models of the glacial-isostatic adjustment (GIA) to past ice-mass changes exhibit large differences in north-east Greenland owing to insufficient knowledge about glacial history and Earth rheology. The GIA uncertainties feed back to uncertainties in present-day mass-balance estimates from satellite gravimetry. Geodetic Global Navigation Satellite System (GNSS) measurements allow to directly observe displacement of bedrock. We present results from repeated and continuous GNSS measurements conducted within five measurement campaigns between 2008 and 2017. We used the observed uplift rates to validate different GIA models in conjunction with estimates of the elastic response of the solid Earth to present-day ice-mass changes. To determine present-day ice-mass changes and the associated elastic deformations, we combined satellite altimetry data from CryoSat-2 with satellite gravimetry data from the Gravity Recovery and Climate Experiment for the entire Greenland Ice Sheet (GrIS) and included peripheral glaciers and ice caps. The different GIA models were consistently used in all processing steps. The GNSS measurements in north-east Greenland revealed uplift rates in the range of 2.8 to 8.9 mm yr−1. The comparison of the total displacement predicted by GIA and elastic modeling with the GNSS-based displacement clearly favors GIA models that show low rates (0.7–4.4 mm yr−1 at the GNSS sites) against GIA models with higher rates of up to 8.3 mm yr−1. The correction due to the favored GIA model in north-east Greenland results in an ice-mass loss of 233 ± 43 Gt yr−1 for the GrIS including peripheral glaciers over the period July 2010 to June 2017.