Metal-Organic Framework/Graphene Quantum Dot Nanoparticles Used for Synergistic Chemo- and Photothermal Therapy

Publikation: Beitrag in FachzeitschriftForschungsartikelBeigetragenBegutachtung

Beitragende

  • Zhengfang Tian - , Huanggang Normal University (Autor:in)
  • Xianxian Yao - , University of Shanghai for Science and Technology (Autor:in)
  • Kexin Ma - , University of Shanghai for Science and Technology (Autor:in)
  • Xingxing Niu - , University of Shanghai for Science and Technology (Autor:in)
  • Julia Grothe - , Professur für Anorganische Chemie (I) (AC1) (Autor:in)
  • Qingni Xu - , Huanggang Normal University (Autor:in)
  • Liansheng Liu - , Huanggang Normal University (Autor:in)
  • Stefan Kaskel - , Professur für Anorganische Chemie (I) (AC1) (Autor:in)
  • Yufang Zhu - , Huanggang Normal University, University of Shanghai for Science and Technology (Autor:in)

Abstract

In this study, a simple one-pot method was used to prepare a multifunctional platform for synergistic chemo- and photothermal therapy, which is composed of zeolitic imidazolate framework-8 (ZIF-8) as drug nanocarriers and the embedded graphene quantum dots (GQDs) as local photothermal seeds. The structure, drug release behavior, photothermal effect, and synergistic therapeutic efficiency of the ZIF-8/GQD nanoparticles were systematically investigated. Using doxorubicin (DOX) as a model anticancer drug, the results showed that monodisperse ZIF-8/GQD nanoparticles with a particle size of 50-100 nm could encapsulate DOX during the synthesis procedure and trigger DOX release under acidic conditions. The DOX-loaded ZIF-8/GQD nanoparticles could efficiently convert near-infrared (NIR) irradiation into heat and thereby increase the temperature. More importantly, with breast cancer 4T1 cells as a model cellular system, the results indicated that the combined chemo- and photothermal therapy with DOX-ZIF-8/GQD nanoparticles exhibited a significant synergistic effect, resulting in a higher efficacy to kill cancer cells compared with chemotherapy and photothermal therapy alone. Hence, ZIF-8/GQD nanoparticles would be promising as versatile nanocarriers for synergistic cancer therapy.

Details

OriginalspracheEnglisch
Seiten (von - bis)1249-1258
Seitenumfang10
FachzeitschriftACS omega
Jahrgang2
Ausgabenummer3
PublikationsstatusVeröffentlicht - 31 März 2017
Peer-Review-StatusJa

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