MEL-28/ELYS is required for the recruitment of nucleoporins to chromatin and postmitotic nuclear pore complex assembly
Publikation: Beitrag in Fachzeitschrift › Forschungsartikel › Beigetragen › Begutachtung
Beitragende
Abstract
The metazoan nuclear envelope (NE) breaks down and re-forms during each cell cycle. Nuclear pore complexes (NPCs), which allow nucleocytoplasmic transport during interphase, assemble into the re-forming NE at the end of mitosis. Using in vitro NE assembly, we show that the vertebrate homologue of MEL-28 (maternal effect lethal), a recently discovered NE component in Caenorhabditis elegans, functions in postmitotic NPC assembly. MEL-28 interacts with the Nup107-160 complex (Nup for nucleoporin), an important building block of the NPC, and is essential for the recruitment of the Nup107-160 complex to chromatin. We suggest that MEL-28 acts as a seeding point for NPC assembly.
Details
Originalsprache | Englisch |
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Seiten (von - bis) | 165-172 |
Seitenumfang | 8 |
Fachzeitschrift | EMBO reports |
Jahrgang | 8 |
Ausgabenummer | 2 |
Publikationsstatus | Veröffentlicht - Feb. 2007 |
Peer-Review-Status | Ja |
Extern publiziert | Ja |
Externe IDs
PubMed | 17235358 |
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ORCID | /0000-0002-4482-6010/work/142251037 |