The use of heterogeneous Multi-Processor System-on-Chip (MPSoC) is a widely accepted solution to address the increasing demands on high performance and energy efficiency for modern embedded devices. To enable the full potential of these platforms, new tools are needed to tackle the programming complexity of MPSoCs, while allowing for high productivity. This chapter discusses the MPSoC Application Programming Studio (MAPS), a framework that provides facilities for expressing parallelism and tool flows for parallelization, mapping/scheduling, and code generation for heterogeneous MPSoCs. Two case studies of the use of MAPS in commercial environments are presented. This chapter closes by discussing early experiences of transferring the MAPS technology into Silexica GmbH, a start-up company that provides multi-core programming tools.