Mapping Research Domain Criteria using a transdiagnostic mini-RDoC assessment in mental disorders: a confirmatory factor analysis

Publikation: Beitrag in FachzeitschriftForschungsartikelBeigetragenBegutachtung


  • Bernd R. Förstner - , Universität Potsdam (Autor:in)
  • Mira Tschorn - , Universität Potsdam (Autor:in)
  • Nicolas Reinoso-Schiller - , Universität Potsdam (Autor:in)
  • Lea Mascarell Maričić - , Charité – Universitätsmedizin Berlin (Autor:in)
  • Erik Röcher - , RWTH Aachen University (Autor:in)
  • Janos L. Kalman - , Ludwig-Maximilians-Universität München (LMU) (Autor:in)
  • Sanna Stroth - , Philipps-Universität Marburg (Autor:in)
  • Annalina V. Mayer - , Universität zu Lübeck (Autor:in)
  • Kristina Schwarz - , Zentralinstitut für Seelische Gesundheit (ZI) (Autor:in)
  • Anna Kaiser - , Zentralinstitut für Seelische Gesundheit (ZI) (Autor:in)
  • Andrea Pfennig - , Klinik und Poliklinik für Psychiatrie und Psychotherapie (Autor:in)
  • André Manook - , Universität Regensburg (Autor:in)
  • Marcus Ising - , Max Planck Institute of Psychiatry (Autor:in)
  • Ingmar Heinig - , Institut für Klinische Psychologie und Psychotherapie (Autor:in)
  • Andre Pittig - , Institut für Klinische Psychologie und Psychotherapie, Friedrich-Alexander-Universität Erlangen-Nürnberg (Autor:in)
  • Andreas Heinz - , Charité – Universitätsmedizin Berlin (Autor:in)
  • Klaus Mathiak - , RWTH Aachen University, Forschungszentrum Jülich (Autor:in)
  • Thomas G. Schulze - , Ludwig-Maximilians-Universität München (LMU) (Autor:in)
  • Frank Schneider - , RWTH Aachen University, Heinrich Heine Universität Düsseldorf (Autor:in)
  • Inge Kamp-Becker - , Philipps-Universität Marburg (Autor:in)
  • Andreas Meyer-Lindenberg - , Zentralinstitut für Seelische Gesundheit (ZI) (Autor:in)
  • Frank Padberg - , Ludwig-Maximilians-Universität München (LMU) (Autor:in)
  • Tobias Banaschewski - , Zentralinstitut für Seelische Gesundheit (ZI) (Autor:in)
  • Michael Bauer - , Klinik und Poliklinik für Psychiatrie und Psychotherapie (Autor:in)
  • Rainer Rupprecht - , Universität Regensburg (Autor:in)
  • Hans Ulrich Wittchen - , Institut für Klinische Psychologie und Psychotherapie, Ludwig-Maximilians-Universität München (LMU) (Autor:in)
  • Michael A. Rapp - , Universität Potsdam (Autor:in)


This study aimed to build on the relationship of well-established self-report and behavioral assessments to the latent constructs positive (PVS) and negative valence systems (NVS), cognitive systems (CS), and social processes (SP) of the Research Domain Criteria (RDoC) framework in a large transnosological population which cuts across DSM/ICD-10 disorder criteria categories. One thousand four hundred and thirty one participants (42.1% suffering from anxiety/fear-related, 18.2% from depressive, 7.9% from schizophrenia spectrum, 7.5% from bipolar, 3.4% from autism spectrum, 2.2% from other disorders, 18.4% healthy controls, and 0.2% with no diagnosis specified) recruited in studies within the German research network for mental disorders for the Phenotypic, Diagnostic and Clinical Domain Assessment Network Germany (PD-CAN) were examined with a Mini-RDoC-Assessment including behavioral and self-report measures. The respective data was analyzed with confirmatory factor analysis (CFA) to delineate the underlying latent RDoC-structure. A revised four-factor model reflecting the core domains positive and negative valence systems as well as cognitive systems and social processes showed a good fit across this sample and showed significantly better fit compared to a one factor solution. The connections between the domains PVS, NVS and SP could be substantiated, indicating a universal latent structure spanning across known nosological entities. This study is the first to give an impression on the latent structure and intercorrelations between four core Research Domain Criteria in a transnosological sample. We emphasize the possibility of using already existing and well validated self-report and behavioral measurements to capture aspects of the latent structure informed by the RDoC matrix.


FachzeitschriftEuropean archives of psychiatry and clinical neuroscience
PublikationsstatusVeröffentlicht - 2022

Externe IDs

PubMed 35778521
Mendeley 29aec6ce-0507-3ef2-a5b7-e3e9486d4504
WOS 000819690600001
ORCID /0000-0002-7762-4327/work/141543449
ORCID /0000-0002-2666-859X/work/146643970
ORCID /0000-0002-3415-5583/work/150329688


Ziele für nachhaltige Entwicklung


  • Confirmatory factor analysis CFA, Diagnosis and classification, PD-CAN, RDoC, Research Domain Criteria, Transdiagnostic, Pd-can