Lysophosphatidic Acid Receptor Is a Functional Marker of Adult Hippocampal Precursor Cells

Publikation: Beitrag in FachzeitschriftForschungsartikelBeigetragenBegutachtung

Beitragende

Abstract

Here, we show that the lysophosphatidic acid receptor 1 (LPA1) is expressed by a defined population of type 1 stem cells and type 2a precursor cells in the adult mouse dentate gyrus. LPA1, in contrast to Nestin, also marks the quiescent stem cell population. Combining LPA1-GFP with EGFR and prominin-1 expression, we have enabled the prospective separation of both proliferative and non-proliferative precursor cell populations. Transcriptional profiling of the isolated proliferative precursor cells suggested immune mechanisms and cytokine signaling as molecular regulators of adult hippocampal precursor cell proliferation. In addition to LPA1 being a marker of this important stem cell population, we also show that the corresponding ligand LPA is directly involved in the regulation of adult hippocampal precursor cell proliferation and neurogenesis, an effect that can be attributed to LPA signaling via the AKT and MAPK pathways.

Details

OriginalspracheEnglisch
Seiten (von - bis)552-565
Seitenumfang14
FachzeitschriftStem Cell Reports
Jahrgang6
Ausgabenummer4
PublikationsstatusVeröffentlicht - 12 Apr. 2016
Peer-Review-StatusJa

Externe IDs

Scopus 84962129394
PubMed 27050949
ORCID /0000-0002-5304-4061/work/161408152

Schlagworte