Low level of exosomal long non-coding RNA HOTTIP is a prognostic biomarker in colorectal cancer

Publikation: Beitrag in FachzeitschriftForschungsartikelBeigetragenBegutachtung

Beitragende

Abstract

Molecular risk stratification of colorectal cancer can improve patient outcome. A panel of lncRNAs (H19, HOTTIP, HULC and MALAT1) derived from serum exosomes of patients with non-metastatic CRC and healthy donors was analyzed. Exosomes from healthy donors carried significantly more H19, HULC and HOTTIP transcripts in comparison to CRC patients. Correlation analysis between lncRNAs and clinical data revealed a statistical significance between low levels of exosomal HOTTIP and poor overall survival. This was confirmed by multivariate analysis that HOTTIP is an independent prognostic marker for overall survival (HR: 4.5, CI: 1.69–11.98, p = 0.0027). Here, HOTTIP poses to be a valid biomarker for patients with a CRC to predict post-surgical survival time.

Details

OriginalspracheEnglisch
Seiten (von - bis)1339-1345
Seitenumfang7
FachzeitschriftRNA biology
Jahrgang16
Ausgabenummer10
PublikationsstatusVeröffentlicht - 3 Okt. 2019
Peer-Review-StatusJa

Externe IDs

PubMed 31251124
ORCID /0000-0001-9389-4688/work/164198933

Schlagworte

Ziele für nachhaltige Entwicklung

ASJC Scopus Sachgebiete

Schlagwörter

  • colorectal cancer, diagnosis, Exosomes, liquid biopsy, long non-coding RNA