Long-Term Overconsumption of Fat and Sugar Causes a Partially Reversible Pre-inflammatory Bowel Disease State

Publikation: Beitrag in FachzeitschriftForschungsartikelBeigetragenBegutachtung

Beitragende

  • Djésia Arnone - , Nutrition Genetics and Exposition NGERE (Autor:in)
  • Marie Vallier - , Christian-Albrechts-Universität zu Kiel (CAU), Max Planck Institute for Evolutionary Biology (Autor:in)
  • Sébastien Hergalant - , Nutrition Genetics and Exposition NGERE (Autor:in)
  • Caroline Chabot - , CHU de Nancy (Autor:in)
  • Ndeye Coumba Ndiaye - , Nutrition Genetics and Exposition NGERE (Autor:in)
  • David Moulin - , IMoPA (Autor:in)
  • Anda-Maria Aignatoaei - , CHU de Nancy (Autor:in)
  • Jean-Marc Alberto - , Nutrition Genetics and Exposition NGERE (Autor:in)
  • Huguette Louis - , Université de Lorraine (Autor:in)
  • Olivier Boulard - , Université de Lille (Autor:in)
  • Camille Mayeur - , Micalis Institute (Autor:in)
  • Natacha Dreumont - , Nutrition Genetics and Exposition NGERE (Autor:in)
  • Kenneth Peuker - , Center for Regenerative Therapies Dresden (CRTD), Professur für Mukosale Immunologie, Universitätsklinikum Carl Gustav Carus Dresden (Autor:in)
  • Anne Strigli - , Center for Regenerative Therapies Dresden (CRTD), Professur für Mukosale Immunologie, Universitätsklinikum Carl Gustav Carus Dresden (Autor:in)
  • Sebastian Zeissig - , Professur für Mukosale Immunologie, Medizinische Klinik und Poliklinik I, Center for Regenerative Therapies Dresden (CRTD), Universitätsklinikum Carl Gustav Carus Dresden (Autor:in)
  • Franck Hansmannel - , Nutrition Genetics and Exposition NGERE (Autor:in)
  • Matthias Chamaillard - , Université de Lille (Autor:in)
  • Tunay Kökten - , Nutrition Genetics and Exposition NGERE (Autor:in)
  • Laurent Peyrin-Biroulet - , Nutrition Genetics and Exposition NGERE (Autor:in)

Abstract

Nutrition appears to be an important environmental factor involved in the onset of inflammatory bowel diseases (IBD) through yet poorly understood biological mechanisms. Most studies focused on fat content in high caloric diets, while refined sugars represent up to 40% of caloric intake within industrialized countries and contribute to the growing epidemics of inflammatory diseases. Herein we aim to better understand the impact of a high-fat-high-sucrose diet on intestinal homeostasis in healthy conditions and the subsequent colitis risk. We investigated the early events and the potential reversibility of high caloric diet-induced damage in mice before experimental colitis. C57BL/6 mice were fed with a high-fat or high-fat high-sucrose or control diet before experimental colitis. In healthy mice, a high-fat high-sucrose diet induces a pre-IBD state characterized by gut microbiota dysbiosis with a total depletion of bacteria belonging to Barnesiella that is associated with subclinical endoscopic lesions. An overall down-regulation of the colonic transcriptome converged with broadly decreased immune cell populations in the mesenteric lymph nodes leading to the inability to respond to tissue injury. Such in-vivo effects on microbiome and transcriptome were partially restored when returning to normal chow. Long-term consumption of diet enriched in sucrose and fat predisposes mice to colitis. This enhanced risk is preceded by gut microbiota dysbiosis and transcriptional reprogramming of colonic genes related to IBD. Importantly, diet-induced transcriptome and microbiome disturbances are partially reversible after switching back to normal chow with persistent sequelae that may contribute to IBD predisposition in the general population.

Details

OriginalspracheEnglisch
Aufsatznummer758518
Seitenumfang19
Fachzeitschrift Frontiers in nutrition : FNUT
Jahrgang8
PublikationsstatusVeröffentlicht - 18 Nov. 2021
Peer-Review-StatusJa

Externe IDs

PubMedCentral PMC8637418
Scopus 85120618638

Schlagworte

ASJC Scopus Sachgebiete