Locally Structured On-Chip Optofluidic Hollow-Core Light Cages for Single Nanoparticle Tracking

Publikation: Beitrag in FachzeitschriftForschungsartikelBeigetragenBegutachtung

Beitragende

  • Jisoo Kim - , Leibniz-Institut für Photonische Technologien, Friedrich-Schiller-Universität Jena (Autor:in)
  • Ronny Förster - , Leibniz-Institut für Photonische Technologien (Autor:in)
  • Torsten Wieduwilt - , Leibniz-Institut für Photonische Technologien (Autor:in)
  • Bumjoon Jang - , Leibniz-Institut für Photonische Technologien, Friedrich-Schiller-Universität Jena (Autor:in)
  • Johannes Bürger - , Ludwig-Maximilians-Universität München (LMU) (Autor:in)
  • Julian Gargiulo - , Ludwig-Maximilians-Universität München (LMU) (Autor:in)
  • Leonardo De S. Menezes - , Ludwig-Maximilians-Universität München (LMU), Universidade Federal de Pernambuco (Autor:in)
  • Christian Rossner - , Leibniz-Institut für Polymerforschung Dresden (Autor:in)
  • Andreas Fery - , Professur für Physikalische Chemie polymerer Materialien (gB/IPF) (PC5), Leibniz-Institut für Polymerforschung Dresden (Autor:in)
  • Stefan A. Maier - , Ludwig-Maximilians-Universität München (LMU), Imperial College London, Monash University (Autor:in)
  • Markus A. Schmidt - , Leibniz-Institut für Photonische Technologien, Friedrich-Schiller-Universität Jena (Autor:in)

Abstract

Nanoparticle tracking analysis (NTA) is a widely used methodology to investigate nanoscale systems at the single species level. Here, we introduce the locally structured on-chip optofluidic hollow-core light cage, as a novel platform for waveguide-assisted NTA. This hollow waveguide guides light by the antiresonant effect in a sparse array of dielectric strands and includes a local modification to realize aberration-free tracking of individual nano-objects, defining a novel on-chip solution with properties specifically tailored for NTA. The key features of our system are (i) well-controlled nano-object illumination through the waveguide mode, (ii) diffraction-limited and aberration-free imaging at the observation site, and (iii) a high level of integration, achieved by on-chip interfacing to fibers. The present study covers all aspects relevant for NTA including design, simulation, implementation via 3D nanoprinting, and optical characterization. The capabilities of the approach to precisely characterize practically relevant nanosystems have been demonstrated by measuring the solvency-induced collapse of a nanoparticle system which includes polymer brush-based shells that react to changes in the liquid environment. Our study unlocks the advantages of the light cage approach in the context of NTA, suggesting its application in various areas such as bioanalytics, life science, environmental science, or nanoscale material science in general.

Details

OriginalspracheEnglisch
Seiten (von - bis)2951-2959
Seitenumfang9
FachzeitschriftACS sensors
Jahrgang7
Ausgabenummer10
PublikationsstatusVeröffentlicht - 28 Okt. 2022
Peer-Review-StatusJa

Externe IDs

PubMed 36260351

Schlagworte

Schlagwörter

  • colloidal analytics, integrated photonics, nanoparticle tracking analysis, optofluidics, waveguiding