L-arginine plasma levels and severity of idiopathic pulmonary arterial hypertension

Publikation: Beitrag in FachzeitschriftForschungsartikelBeigetragenBegutachtung



BACKGROUND: Idiopathic pulmonary arterial hypertension (iPAH) is a rare disease of unknown aetiology characterized by a poor prognosis. Impairment of nitric oxide (NO) synthesis or NO-induced vasorelaxation has been suspected to play a role in the development of iPAH. This study was performed to investigate possible correlations between the plasma levels of the NO-related aminoacids L-arginine, L-citrulline and N-hydroxy-L-arginine (L-NHA) and the severity of iPAH.

METHODS: In twelve iPAH patients hemodynamics were measured by right heart catheterization, and plasma levels of L-arginine, L-citrulline and L-NHA were determined in blood samples from the pulmonary artery, peripheral artery and peripheral vein by high-performance liquid chromatography analysis. In eight of twelve patients a six minute walk test was performed.

RESULTS: Plasma levels of L-arginine strongly correlated to right atrial pressure, cardiac output, cardiac index, mixed-venous oxygen saturation, six minute walk data and NYHA functional class at all sites of blood sampling (p < 0.05).

CONCLUSIONS: The results suggest a possible role of the NO precursor L-arginine in the pathogenesis of iPAH.


Seiten (von - bis)61-67
FachzeitschriftVasa - European Journal of Vascular Medicine
PublikationsstatusVeröffentlicht - Feb. 2008

Externe IDs

Scopus 40349098047
PubMed 18512543
researchoutputwizard legacy.publication#24980
ORCID /0000-0001-6022-6827/work/142659535



  • Adult, Aged, Arginine/analogs & derivatives, Biomarkers, Blood Pressure, Cardiac Catheterization, Chromatography, High Pressure Liquid, Citrulline/blood, Cohort Studies, Exercise Test, Female, Hemodynamics, Humans, Hypertension, Pulmonary/blood, Male, Middle Aged, Pilot Projects, Pulmonary Artery/physiopathology, Severity of Illness Index