Juggling with lipids, a game of Russian roulette

Publikation: Beitrag in FachzeitschriftÜbersichtsartikel (Review)BeigetragenBegutachtung

Beitragende

  • Maceler Aldrovandi - , Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (Autor:in)
  • Maria Fedorova - , Universität Leipzig (Autor:in)
  • Marcus Conrad - , Pirogov Russian National Research Medical University, Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (Autor:in)

Abstract

Lipid peroxidation (LPO) is the molecular mechanism involved in oxidative damage of cellular membranes and the hallmark of a nonapoptotic form of cell death, known as ferroptosis. This iron-dependent cell death is an emerging strategy in cancer treatment and one of the central cell death mechanisms accounting for early cell loss and organ dysfunction in both neurodegenerative disease and ischemia-reperfusion injury. Although the biological roles of LPO products have attracted considerable attention, not only for their pathological mechanisms but also for their potential clinical application as biomarkers, the existence of a common lethal lipid death signal generated during ferroptosis remains poorly explored. A better understanding of the LPO process, however, may unleash unprecedented opportunities for therapeutic intervention of as-yet incurable diseases.

Details

OriginalspracheEnglisch
Seiten (von - bis)463-473
Seitenumfang11
FachzeitschriftTrends in Endocrinology and Metabolism
Jahrgang32
Ausgabenummer7
PublikationsstatusVeröffentlicht - Juli 2021
Peer-Review-StatusJa
Extern publiziertJa

Externe IDs

Scopus 85105559585
ORCID /0000-0002-4692-3885/work/149081298

Schlagworte

Ziele für nachhaltige Entwicklung

Schlagwörter

  • Ferroptosis, Humans, Lipid Peroxidation, Lipids, Neurodegenerative Diseases

Bibliotheksschlagworte