Itch, sleep loss, depressive symptoms, fatigue, and productivity loss in patients with moderate-to-severe atopic dermatitis: Analyses of TREATgermany registry data
Publikation: Beitrag in Fachzeitschrift › Forschungsartikel › Beigetragen › Begutachtung
Beitragende
- Universitätsklinikum Schleswig-Holstein Campus Kiel
- Practice Dr. med. Magnus Bell
- Hautmedizin Bad Soden Studienzentrum
- Practice Dr. Med. Christiane Handrick
- Practice Dr. med. Andrea Asmussen
- Universitätsklinikum Düsseldorf
- Practice Dr. med. Sung-Hei Hong-Weldemann
- Universitätsklinikum Hamburg-Eppendorf (UKE)
- Universität Heidelberg
- Practice Dr. med. Thomas Schaefer/ Dr. med. Doreen Belz
- Practice Dr. Med. Beate Schwarz
- Practice Dr. med. Franca Wiemers
- Practice Dr. med. Jens-Joachim Brücher
- Helix Medical Ecellence Center Mainz
- Technische Universität München
- Hautarztpraxis Dr. Ertner
- Charité – Universitätsmedizin Berlin
- Universitätsklinikum der Friedrich-Alexander-Universität Erlangen-Nürnberg
- Elbeklinikum Stade/Buxtehude
- Universität Bielefeld
- Universitätsklinikum Heidelberg
- Klinikum der Ludwig-Maximilians-Universität (LMU) München
- Company for Medical Study and Service Selters
- Medizinische Hochschule Hannover (MHH)
- Leibniz Universität Hannover (LUH)
Abstract
BACKGROUND: TREATgermany is a multicenter registry including patients with moderate-to-severe atopic dermatitis (AD) from currently 74 study centers (university clinics, hospitals and practices) in Germany. As of August 31, 2021, 1,230 adult patients were enrolled.
METHODS: In TREATgermany, patients and physicians fill in questionnaires pertaining to symptoms, disease severity, quality of life, depressiveness, and fatigue. In particular, limitations in work performance are assessed using the Work Limitations Questionnaire (WLQ). To assess associations between occupational performance/work limitations and symptoms, correlations and regression models were calculated.
RESULTS: The examined sample of 228 employed patients reported an average of 6% at-work productivity loss within the past two weeks prior to enrolment in the registry. The WLQ productivity loss score was moderately associated with itch (r = 0.32) and sleep loss (r = 0.39) and strongly associated with depressive symptoms (r = 0.68) and fatigue (r = 0.60).
CONCLUSIONS: The analyses of the registry data show that moderate-to-severe atopic dermatitis has a negative impact on the work productivity of the patients. The analyses further point out the relevant associations between work productivity, depressive symptoms, and fatigue highlighting the disease burden caused by the psychological components of AD.
Details
Originalsprache | Englisch |
---|---|
Seiten (von - bis) | 1157-1168 |
Seitenumfang | 12 |
Fachzeitschrift | JDDG - Journal of the German Society of Dermatology |
Jahrgang | 21 |
Ausgabenummer | 10 |
Frühes Online-Datum | 23 Juli 2023 |
Publikationsstatus | Veröffentlicht - Okt. 2023 |
Peer-Review-Status | Ja |
Externe IDs
Scopus | 85165579261 |
---|---|
Mendeley | acaead4f-de9f-3298-905d-4ea960b18473 |
ORCID | /0000-0001-7457-6481/work/142246230 |
ORCID | /0000-0002-4049-9120/work/142248606 |
PubMed | 37485573 |
Schlagworte
Forschungsprofillinien der TU Dresden
ASJC Scopus Sachgebiete
Schlagwörter
- Atopic dermatitis, productivity loss, registry, work limitations, Severity of Illness Index, Fatigue/epidemiology, Humans, Routinely Collected Health Data, Dermatitis, Atopic/diagnosis, Sleep, Depression/epidemiology, Quality of Life, Adult, Pruritus/etiology