Urodele amphibians have long served as key models for regenerative, developmental and evolutionary biology research. Recent studies have uncovered the induction of cellular senescence during limb regeneration. The dynamics of senescence in this context reflects that observed in acute senescence, suggesting that senescent cells may play positive roles in regeneration. Further, salamanders possess a highly robust and efficient mechanism for senescent cell surveillance and clearance. Given the causal role of chronic senescence in ageing and age-related pathologies, it is of therapeutic interest to understand the mechanisms and regulation underlying this clearance mechanism. Here, we discuss what is known about cellular senescence in salamanders, what these organisms can offer towards understanding the roles of cellular senescence in regeneration, and howthey can serve as informative models for senescence-based therapeutic approaches.