Percutaneous defect closure is well established in patients with a symptomatic patent foramen ovale (PFO). Despite a safe interventional procedure, severe complications have been described during device implantation or follow up. Two patients are described whose cases may serve to warn of an unusual complication associated with a closure device. Several weeks after percutaneous PFO closure, perforation of a device strut into the aortic root was evident in both asymptomatic patients. The perforations were repaired surgically and both patients had further uneventful followups. Procedures which could decrease the risk of device perforation should be adhered to and the indication for closure should consider this potential complication.