Integrin-mediated cell-matrix interactions for prosurvival and antiapoptotic signaling after genotoxic injury
Publikation: Beitrag in Fachzeitschrift › Übersichtsartikel (Review) › Beigetragen › Begutachtung
Beitragende
Abstract
Interactions of cells with their microenvironment modify the cellular sensitivity of normal and tumor cells for radiation- and drug-induced genotoxic injury. The preexistent or acquired cellular resistance against such agents aggravates anticancer therapies and, therefore, complicates the recovery of patients. Recently, integrin-mediated adhesion was shown to improve cell survival of both normal and cancer cells following DNA damage. Here, I will discuss the role of integrins and integrin-mediated signaling cascades in the survival or death response upon genotoxic stress. Detailed knowledge of the responsible molecular processes might provide implications for putative therapies targeting integrins or integrin-associated molecules to achieve an optimization of anticancer treatments.
Details
Originalsprache | Englisch |
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Seiten (von - bis) | 11-9 |
Seitenumfang | 9 |
Fachzeitschrift | Cancer letters |
Jahrgang | 242 |
Ausgabenummer | 1 |
Publikationsstatus | Veröffentlicht - 8 Okt. 2006 |
Peer-Review-Status | Ja |
Externe IDs
Scopus | 33748049409 |
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ORCID | /0000-0001-5684-629X/work/147143561 |
Schlagworte
Ziele für nachhaltige Entwicklung
Schlagwörter
- Antineoplastic Agents/pharmacology, Apoptosis, Cell Adhesion, Cell Line, Tumor, Cell Proliferation, Cell Survival, DNA Damage, Extracellular Matrix/metabolism, Gene Expression Regulation, Neoplastic, Humans, Integrins/biosynthesis, Models, Biological, Neoplasm Metastasis, Neoplasms/chemically induced, Signal Transduction