New technologies for distributed object computing (DOC) challenge new approaches to integrate Geographical Information Systems (GIS) and simulation tools for spatio-temporal modeling. Several standardization initiatives work on specifying interfaces and defining service architectures for appropriate components. Currently, the most promising attempts are represented by the OpenGIS and the High Level Architecture. This paper gives a brief survey of the current state of the emerging standards, highlights the advantages and shortcomings of these attempts, and defines a possible framework for GIS-integrated simulation of spatio-temporal processes. Two abstraction layers provide interfaces for different GIS kernels and allow the integration of different simulation models. A prototype implementation of the specified interfaces shows the integration of analysis tools and two different simulation strategies: a mesoscale boundary layer model based on the Navier-Stokes equation and a cellular automata to simulate air pollutant dispersion.