Integrated analysis of transcriptome and epigenome reveals ENSR00000272060 as a potential biomarker in gastric cancer

Publikation: Beitrag in FachzeitschriftForschungsartikelBeigetragenBegutachtung

Beitragende

Abstract

Background: Enhancer RNAs (eRNAs) are involved in gene expression regulation. Although functional roles of eRNAs in the pathophysiology of neoplasms have been reported, their involvement in gastric cancer (GC) is less known. Materials & methods: A network-based integrative approach was utilized for analyzing transcriptome and epigenome alterations in GC, and an eRNA was selected for experimental validation. Survival analysis and clinicopathological associations were also performed. Results: A hub eRNA, ENSR00000272060, showed significantly increased expression in tumor versus nontumor tissues, as well as an association with clinicopathological features. A seven-gene prognostic model was also constructed. Conclusion: The constructed network provides a comprehensive understanding of the underlying processes implicated in the progression of GC, along with a starting point from which to derive potential diagnostic/prognostic biomarkers.

Details

OriginalspracheEnglisch
Seiten (von - bis)159-173
Seitenumfang15
FachzeitschriftEpigenomics
Jahrgang16
Ausgabenummer3
PublikationsstatusVeröffentlicht - Feb. 2024
Peer-Review-StatusJa

Externe IDs

ORCID /0000-0002-1887-4772/work/152545586
Scopus 85184144134

Schlagworte

Ziele für nachhaltige Entwicklung

Schlagwörter

  • Humans, Stomach Neoplasms/genetics, Transcriptome, Epigenome, Gene Expression Regulation, Neoplastic, Biomarkers, Tumor/genetics