The development of thermal systems with effective physical moisture protection is an important part of research at the Institute of Building Climatology at the Dresden University of Technology. The use of extensive measurement technique enables the monitoring of the hygrothermal effects of energetic retrofitting measures. Additionally the validation of the physical models and simulation codes developed at the institute for the coupled heat and moisture balance of building constructions becomes possible.Selected results for buildings in Dresden, Senftenberg, Nuremberg, Ebersbach (East Saxony), and Edemissen (nar Hanover) are presented in this contribution.