Induction and Characterization of Cellular Senescence in Salamanders

Publikation: Beitrag in FachzeitschriftForschungsartikelEingeladenBegutachtung

Abstract

Cellular senescence is a permanent proliferation arrest mechanism induced following the detection of genotoxic stress. Mounting evidence has causally linked the accumulation of senescent cells to a growing number of age-related pathologies in mammals. However, recent data have also highlighted senescent cells as important mediators of tissue remodeling during organismal development, tissue repair, and regeneration. As powerful model organisms for studying such processes, salamanders constitute a system in which to probe the characteristics, physiological functions, and evolutionary facets of cellular senescence. In this chapter, we outline methods for the generation, identification, and characterization of salamander senescent cells in vitro and in vivo.

Details

OriginalspracheEnglisch
Seiten (von - bis)135-154
Seitenumfang20
FachzeitschriftMethods in molecular biology (Clifton, N.J.)
Jahrgang2023
Ausgabenummer2562
PublikationsstatusVeröffentlicht - 23 Okt. 2022
Peer-Review-StatusJa

Externe IDs

Scopus 85140349681
Mendeley 772aaecb-7571-3014-8965-23fac52ac355