Impact of Vaccination Status on Outcome of Patients With COVID-19 and Acute Ischemic Stroke Undergoing Mechanical Thrombectomy

Publikation: Beitrag in FachzeitschriftForschungsartikelBeigetragenBegutachtung

Beitragende

  • Cornelius Deuschl - , Universitätsklinikum Essen (Autor:in)
  • Lukas Goertz - , Universitätsklinikum Köln (Autor:in)
  • Christoph Kabbasch - , Universitätsklinikum Köln (Autor:in)
  • Martin Köhrmann - , Universitätsklinikum Essen (Autor:in)
  • Christoph Kleinschnitz - , Universitätsklinikum Essen (Autor:in)
  • Ansgar Berlis - , Universitätsklinikum Augsburg (Autor:in)
  • Christoph Johannes Maurer - , Universitätsklinikum Augsburg (Autor:in)
  • Iris Mühlen - , Universitätsklinikum der Friedrich-Alexander-Universität Erlangen-Nürnberg (Autor:in)
  • Bernd Kallmünzer - , Universitätsklinikum der Friedrich-Alexander-Universität Erlangen-Nürnberg (Autor:in)
  • Matthias Gawlitza - , Universitätsklinikum Leipzig (Autor:in)
  • Daniel P O Kaiser - , Institut und Poliklinik für Diagnostische und Interventionelle Neuroradiologie (Autor:in)
  • Joachim Klisch - , Helios Helios Klinikum Erfurt (Autor:in)
  • Donald Lobsien - , Helios Helios Klinikum Erfurt (Autor:in)
  • Daniel Behme - , Universitätsklinikum Magdeburg (Autor:in)
  • Maximilian Thormann - , Universitätsklinikum Magdeburg (Autor:in)
  • Fabian Flottmann - , Universitätsklinikum Hamburg-Eppendorf (UKE) (Autor:in)
  • Laurens Winkelmeier - , Universitätsklinikum Hamburg-Eppendorf (UKE) (Autor:in)
  • Elke Ruth Gizewski - , Medizinische Universität Innsbruck (Autor:in)
  • Lukas Mayer-Suess - , Medizinische Universität Innsbruck (Autor:in)
  • Markus Holtmannspoetter - , Klinikum Nurnberg (Autor:in)
  • Christoph Moenninghoff - , Johannes Wesling Klinikum Minden (Autor:in)
  • Martin Schlunz-Hendann - , Sana Kliniken Duisburg (Autor:in)
  • Dominik Grieb - , Medizinische Hochschule Hannover (MHH) (Autor:in)
  • Christophe T Arendt - , Universitätsklinikum Frankfurt (Autor:in)
  • Ferdinand O Bohmann - , Universitätsklinikum Frankfurt (Autor:in)
  • Jens Altenbernd - , Gemeinschaftskrankenhaus Herdecke (Autor:in)
  • Yan Li - (Autor:in)
  • Ulrich Sure - , Universitätsklinikum Essen (Autor:in)
  • Ruben Mühl-Benninghaus - , Klinikum Lueneburg (Autor:in)
  • Thomas Rodt - , Klinikum Lueneburg (Autor:in)
  • Kai Kallenberg - , Klinikum Fulda gAG (Autor:in)
  • Alexandru Durutya - , Klinikum Fulda gAG (Autor:in)
  • Mohamed Elsharkawy - , Universitätsklinikum Münster (Autor:in)
  • Christian-Paul Stracke - , Universitätsklinikum Münster (Autor:in)
  • Mathias Gerhard Schumann - , Vivantes Klinikum im Friedrichshain (Autor:in)
  • Alexander Bock - , Vivantes Klinikum im Friedrichshain (Autor:in)
  • Omid Nikoubashman - , RWTH Aachen University (Autor:in)
  • Martin Wiesmann - , RWTH Aachen University (Autor:in)
  • Hans Henkes - , Klinikum Stuttgart (Autor:in)
  • Sebastian Dolff - , Universitätsklinikum Essen (Autor:in)
  • Aydin Demircioglu - , Universitätsklinikum Essen (Autor:in)
  • Michael Forsting - , Universitätsklinikum Essen (Autor:in)
  • Hanna Styczen - , Universitätsklinikum Essen (Autor:in)

Abstract

BACKGROUND: Data on impact of COVID-19 vaccination and outcomes of patients with COVID-19 and acute ischemic stroke undergoing mechanical thrombectomy are scarce. Addressing this subject, we report our multicenter experience.

METHODS AND RESULTS: This was a retrospective analysis of patients with COVID-19 and known vaccination status treated with mechanical thrombectomy for acute ischemic stroke at 20 tertiary care centers between January 2020 and January 2023. Baseline demographics, angiographic outcome, and clinical outcome evaluated by the modified Rankin Scale score at discharge were noted. A multivariate analysis was conducted to test whether these variables were associated with an unfavorable outcome, defined as modified Rankin Scale score >3. A total of 137 patients with acute ischemic stroke (48 vaccinated and 89 unvaccinated) with acute or subsided COVID-19 infection who underwent mechanical thrombectomy attributable to vessel occlusion were included in the study. Angiographic outcomes between vaccinated and unvaccinated patients were similar (modified Thrombolysis in Cerebral Infarction ≥2b: 85.4% in vaccinated patients versus 86.5% in unvaccinated patients; P=0.859). The rate of functional independence (modified Rankin Scale score, ≤2) was 23.3% in the vaccinated group and 20.9% in the unvaccinated group (P=0.763). The mortality rate was 30% in both groups. In the multivariable analysis, vaccination status was not a significant predictor for an unfavorable outcome (P=0.957). However, acute COVID-19 infection remained significant (odds ratio, 1.197 [95% CI, 1.007-1.417]; P=0.041).

CONCLUSIONS: Our study demonstrated no impact of COVID-19 vaccination on angiographic or clinical outcome of COVID-19-positive patients with acute ischemic stroke undergoing mechanical thrombectomy, whereas worsening attributable to COVID-19 was confirmed.

Details

OriginalspracheEnglisch
Seiten (von - bis)e031816
FachzeitschriftJournal of the American Heart Association
Jahrgang13
Ausgabenummer9
Frühes Online-Datum19 Apr. 2024
PublikationsstatusVeröffentlicht - 7 Mai 2024
Peer-Review-StatusJa

Externe IDs

ORCID /0000-0001-5258-0025/work/158306263
unpaywall 10.1161/jaha.123.031816
Scopus 85192401135

Schlagworte

Ziele für nachhaltige Entwicklung

Schlagwörter

  • COVID-19/complications, Humans, Middle Aged, Vaccination, Male, Treatment Outcome, SARS-CoV-2, Thrombectomy, Aged, 80 and over, Female, Aged, COVID-19 Vaccines/adverse effects, Ischemic Stroke/mortality, Retrospective Studies