Impact of complete surgical resection on outcome in aggressive non-Hodgkin lymphoma treated with immunochemotherapy
Publikation: Beitrag in Fachzeitschrift › Forschungsartikel › Beigetragen › Begutachtung
Beitragende
Abstract
BACKGROUND: Surgical resection is considered to be of purely diagnostic value in aggressive lymphoma. Evidence for an impact on outcome is scant and restricted to retrospective observations.
METHODS: In the "Positron Emission Tomography-guided Therapy of Aggressive non-Hodgkin Lymphomas" (PETAL) trial, patients with a negative baseline positron emission tomography (PET) scan were documented in a prospective observational substudy. Baseline PET-negative patients with the absence of lymph node enlargement on computed tomography and a negative bone marrow biopsy were considered to have undergone complete lymphoma resection.
RESULTS: Eighty-two of 1,041 patients (7.9%) had a negative baseline PET scan, and 67 were included in this analysis. All were treated with cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP), plus rituximab for CD20-positive lymphomas. Among 52 patients with diffuse large B-cell lymphoma (DLBCL), 48 had completely resected disease. Their outcome tended to be better than that of 115 baseline PET-positive stage I DLBCL patients treated in the main part of the PETAL trial (2-year progression-free survival 92.7% [95% confidence interval 84.7-100] versus 88.4% [82.5-94.3], P = .056; 2-year overall survival 92.7% [84.7-100] versus 93.7% [89.2-98.2], P = .176), but this was restricted to patients below the age of 60 years (2-year progression-free survival 100% versus 92.2% [84.8-99.6], P = .031; 2-year overall survival 100% versus 95.9% [90.2-100], P = .075). In peripheral T-cell lymphoma, eight of 11 patients had completely resected disease. In contrast to DLBCL, complete resection was not associated with improved outcome compared to the control.
CONCLUSION: Young patients with early stage DLBCL may benefit from complete lymphoma resection prior to immunochemotherapy.
Details
Originalsprache | Englisch |
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Seiten (von - bis) | 8386-8396 |
Seitenumfang | 11 |
Fachzeitschrift | Cancer medicine |
Jahrgang | 9 |
Ausgabenummer | 22 |
Publikationsstatus | Veröffentlicht - Nov. 2020 |
Peer-Review-Status | Ja |
Externe IDs
PubMedCentral | PMC7666729 |
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Scopus | 85090984594 |
Schlagworte
Schlagwörter
- Adult, Aged, Antineoplastic Combined Chemotherapy Protocols/adverse effects, Biopsy, Bone Marrow Examination, Cyclophosphamide/adverse effects, Disease Progression, Doxorubicin/adverse effects, Female, Germany, Humans, Immunotherapy/adverse effects, Lymphoma, B-Cell/diagnostic imaging, Lymphoma, T-Cell/diagnostic imaging, Male, Middle Aged, Neoplasm Staging, Positron-Emission Tomography, Prednisone/adverse effects, Progression-Free Survival, Prospective Studies, Randomized Controlled Trials as Topic, Time Factors, Vincristine/adverse effects