To remain competitive, companies today are increasingly faced with the challenge of reacting adequately in dynamic development environments. For product development, in particular, it is necessary to organize decision-making processes so they can react quickly and flexibly to changes in the development environment. To describe the dynamics and changeability, the term VUCA is used, which is a synonym for volatility, uncertainty, complexity, and ambiguity, and thus summarises the most diverse forms of changeability. An adaptation of agile methods to the development context makes it necessary to specify the causes of uncertainty in more detail. The article presents a framework that analyses these influencing factors and differentiates them more precisely to specify problems in dealing with VUCA and to develop recommendations for action for the goal-oriented adaptation of agile methods.