Humanised xenograft models of bone metastasis revisited: Novel insights into species-specific mechanisms of cancer cell osteotropism

Publikation: Beitrag in FachzeitschriftForschungsartikelBeigetragenBegutachtung

Beitragende

  • Boris Michael Holzapfel - , Queensland University of Technology, Julius-Maximilians-Universität Würzburg (Autor:in)
  • Laure Thibaudeau - , Queensland University of Technology (Autor:in)
  • Parisa Hesami - , Queensland University of Technology (Autor:in)
  • Anna Taubenberger - , Professur für Zelluläre Maschinen (Autor:in)
  • Nina Pauline Holzapfel - , Queensland University of Technology (Autor:in)
  • Susanne Mayer-Wagner - , Ludwig-Maximilians-Universität München (LMU) (Autor:in)
  • Carl Power - , University of New South Wales (Autor:in)
  • Judith Clements - , Queensland University of Technology (Autor:in)
  • Pamela Russell - , Queensland University of Technology (Autor:in)
  • Dietmar Werner Hutmacher - , Queensland University of Technology, Georgia Institute of Technology, Technische Universität München (Autor:in)

Abstract

The determinants and key mechanisms of cancer cell osteotropism have not been identified, mainly due to the lack of reproducible animal models representing the biological, genetic and clinical features seen in humans. An ideal model should be capable of recapitulating as many steps of the metastatic cascade as possible, thus facilitating the development of prognostic markers and novel therapeutic strategies. Most animal models of bone metastasis still have to be derived experimentally as most syngeneic and transgeneic approaches do not provide a robust skeletal phenotype and do not recapitulate the biological processes seen in humans. The xenotransplantation of human cancer cells or tumour tissue into immunocompromised murine hosts provides the possibility to simulate early and late stages of the human disease. Human bone or tissue-engineered human bone constructs can be implanted into the animal to recapitulate more subtle, species-specific aspects of the mutual interaction between human cancer cells and the human bone microenvironment. Moreover, the replication of the entire "organ" bone makes it possible to analyse the interaction between cancer cells and the haematopoietic niche and to confer at least a partial human immunity to the murine host. This process of humanisation is facilitated by novel immunocompromised mouse strains that allow a high engraftment rate of human cells or tissue. These humanised xenograft models provide an important research tool to study human biological processes of bone metastasis.

Details

OriginalspracheEnglisch
Seiten (von - bis)129-145
Seitenumfang17
Fachzeitschrift Cancer and metastasis reviews
Jahrgang32
Ausgabenummer1-2
PublikationsstatusVeröffentlicht - Juni 2013
Peer-Review-StatusJa

Externe IDs

PubMed 23657538

Schlagworte

Ziele für nachhaltige Entwicklung

ASJC Scopus Sachgebiete

Schlagwörter

  • Bone graft, Bone metastasis, Haematopoiesis, Humanised, Xenograft model