The Harmonising Outcomes Measurement in Eczema (HOME) initiative developed a core outcome set (COS) for atopic dermatitis (AD), but uptake in trials is still limited. An online survey was sent out to corresponding authors of AD interventional randomized clinical trials to assess their awareness of the HOME COS, evaluate barriers to uptake and identify facilitators to enhance implementation. Survey respondents emphasized increasing awareness of the COS in the research community, reducing the burden associated with using the COS and ensuring applicability to diverse populations.