Health related quality of life following open versus minimally invasive total gastrectomy for cancer: Results from a randomized clinical trial

Publikation: Beitrag in FachzeitschriftForschungsartikelBeigetragenBegutachtung

Beitragende

  • Nicole van der Wielen - , University of Amsterdam (Autor:in)
  • Freek Daams - , University of Amsterdam (Autor:in)
  • Riccardo Rosati - , Vita-Salute San Raffaele University (Autor:in)
  • Paolo Parise - , Vita-Salute San Raffaele University (Autor:in)
  • Jürgen Weitz - , Klinik und Poliklinik für Viszeral- Thorax- und Gefäßchirurgie, Universitätsklinikum Carl Gustav Carus Dresden (Autor:in)
  • Christoph Reissfelder - , Universität Heidelberg (Autor:in)
  • Ismael Diez del Val - , Hospital de Basurto (Autor:in)
  • Carlos Loureiro - , Hospital de Basurto (Autor:in)
  • Purificación Parada-González - , Complejo Hospitalario Universitario de Santiago de Compostela (C.H.U.S.) (Autor:in)
  • Elena Pintos-Martínez - , Complejo Hospitalario Universitario de Santiago de Compostela (C.H.U.S.) (Autor:in)
  • Francisco Mateo Vallejo - , Hospital Universitario De Jerez (Autor:in)
  • Carlos Medina Achirica - , Hospital Universitario De Jerez (Autor:in)
  • Andrés Sánchez-Pernaute - , Complutense University (Autor:in)
  • Adriana Ruano Campos - , Complutense University (Autor:in)
  • Luigi Bonavina - , Gruppo San Donato (Autor:in)
  • Emanuele L.G. Asti - , Gruppo San Donato (Autor:in)
  • Alfredo Alonso Poza - , Hospital Universitario del Sureste (Autor:in)
  • Carlos Gilsanz - , Hospital Universitario del Sureste (Autor:in)
  • Magnus Nilsson - , Karolinska Institutet (Autor:in)
  • Mats Lindblad - , Karolinska Institutet (Autor:in)
  • Suzanne S. Gisbertz - , University of Amsterdam (Autor:in)
  • Mark I. van Berge Henegouwen - , University of Amsterdam (Autor:in)
  • Uberto Fumagalli Romario - , IRCCS Istituto Europeo di Oncologia - Milano (Autor:in)
  • Stefano De Pascale - , IRCCS Istituto Europeo di Oncologia - Milano (Autor:in)
  • Khurshid Akhtar - , Northern Care Alliance NHS Group (Autor:in)
  • H. Jaap Bonjer - , University of Amsterdam (Autor:in)
  • Miguel A. Cuesta - , University of Amsterdam (Autor:in)
  • Donald L. van der Peet - , University of Amsterdam (Autor:in)
  • Jennifer Straatman - , University of Amsterdam (Autor:in)

Abstract

Introduction: Minimally invasive techniques show improved short-term and comparable long-term outcomes compared to open techniques in the treatment of gastric cancer and improved survival has been seen with the implementation of multimodality treatment. Therefore, focus of research has shifted towards optimizing treatment regimens and improving quality of life. Materials and methods: A randomized trial was performed in thirteen hospitals in Europe. Patients were randomized between open total gastrectomy (OTG) or minimally invasive total gastrectomy (MITG) after neoadjuvant chemotherapy. This study investigated patient reported outcome measures (PROMs) on health-related quality of life (HRQoL) following OTG or MITG, using the Euro-Qol-5D (EQ-5D) and the European Organization for Research and Treatment of Cancer (EORTC) questionnaires, modules C30 and STO22. Due to multiple testing a p-value < 0.001 was deemed statistically significant. Results: Between January 2015 and June 2018, 96 patients were included in this trial. Forty-nine patients were randomized to OTG and 47 to MITG. A response compliance of 80% was achieved for all PROMs. The EQ5D overall health score one year after surgery was 85 (60–90) in the open group and 68 (50–83.8) in the minimally invasive group (P = 0.049). The median EORTC-QLQ-C30 overall health score one year postoperatively was 83,3 (66,7–83,3) in the open group and 58,3 (35,4–66,7) in the minimally invasive group (P = 0.002). This was not statistically significant. Conclusion: No differences were observed between open total gastrectomy and minimally invasive total gastrectomy regarding HRQoL data, collected using the EQ-5D, EORTC QLQ-C30 and EORTC-QLQ-STO22 questionnaires.

Details

OriginalspracheEnglisch
Seiten (von - bis)553-560
Seitenumfang8
FachzeitschriftEuropean journal of surgical oncology
Jahrgang2022
Ausgabenummer48(3)
PublikationsstatusVeröffentlicht - März 2022
Peer-Review-StatusJa

Externe IDs

PubMed 34503850

Schlagworte

Ziele für nachhaltige Entwicklung

ASJC Scopus Sachgebiete

Schlagwörter

  • Gastric cancer, Minimally invasive gastrectomy, Open gastrectomy, Quality of life

Bibliotheksschlagworte