Graphene, other carbon nanomaterials and the immune system: Toward nanoimmunity-by-design

Publikation: Beitrag in FachzeitschriftForschungsartikelBeigetragenBegutachtung

Beitragende

  • Arianna Gazzi - , Università degli Studi di Trieste, Città della Speranza, Ikerbasque Basque Foundation for Science (Autor:in)
  • Laura Fusco - , Università degli Studi di Trieste, Città della Speranza, Sidra Medical and Research Center, Ikerbasque Basque Foundation for Science (Autor:in)
  • Marco Orecchioni - , La Jolla Institute for Allergy and Immunology, University of Sassari (Autor:in)
  • Silvia Ferrari - , University of Sassari (Autor:in)
  • Giulia Franzoni - , Experimental Zooprophylactic Institute of Sardinia (Autor:in)
  • J. Stephen Yan - , Rice University (Autor:in)
  • Matthias Rieckher - , Universität zu Köln (Autor:in)
  • Guotao Peng - , Karolinska Institutet (Autor:in)
  • Matteo Andrea Lucherelli - , Université de Strasbourg (Autor:in)
  • Isabella Anna Vacchi - , Université de Strasbourg (Autor:in)
  • Ngoc Do Quyen Chau - , Université de Strasbourg (Autor:in)
  • Alejandro Criado - , CIC biomaGUNE (Autor:in)
  • Akcan Istif - , Università degli Studi di Trieste (Autor:in)
  • Donato Mancino - , CIC biomaGUNE (Autor:in)
  • Antonio Dominguez - , CIC biomaGUNE (Autor:in)
  • Hagen Eckert - , Technische Universität Dresden (Autor:in)
  • Ester Vázquez - , University of Castilla-La Mancha (Autor:in)
  • Tatiana Da Ros - , Università degli Studi di Trieste (Autor:in)
  • Paola Nicolussi - , Experimental Zooprophylactic Institute of Sardinia (Autor:in)
  • Vincenzo Palermo - , National Research Council of Italy (CNR), Chalmers University of Technology (Autor:in)
  • Björn Schumacher - , Universität zu Köln (Autor:in)
  • Gianaurelio Cuniberti - , Professur für Materialwissenschaft und Nanotechnik, Max Bergmann Zentrum für Biomaterialien Dresden (MBZ), Technische Universität Dresden (Autor:in)
  • Yiyong Mai - , Shanghai Jiao Tong University (Autor:in)
  • Cecilia Clementi - , Rice University (Autor:in)
  • Matteo Pasquali - , Rice University (Autor:in)
  • Xinliang Feng - , Center for Advancing Electronics Dresden (cfaed), Professur für Molekulare Funktionsmaterialien (cfaed) (Autor:in)
  • Kostas Kostarelos - , University of Manchester, Catalan Institute of Nanoscience and Nanotechnology (Autor:in)
  • Acelya Yilmazer - , Ankara University (Autor:in)
  • Davide Bedognetti - , Sidra Medical and Research Center (Autor:in)
  • Bengt Fadeel - , Karolinska Institutet (Autor:in)
  • Maurizio Prato - , Università degli Studi di Trieste, CIC biomaGUNE, Ikerbasque Basque Foundation for Science (Autor:in)
  • Alberto Bianco - , Université de Strasbourg (Autor:in)
  • Lucia Gemma Delogu - , Città della Speranza, University of Sassari, Università degli studi di Padova (Autor:in)

Abstract

Carbon-based materials (CBMs), such as graphene, nanodiamonds, carbon fibers, and carbon dots, have attracted a great deal scientific attention due to their potential as biomedical tools. Following exposure, particularly intravenous injection, these nanomaterials can be recognized by immune cells. Such interactions could be modulated by the different physicochemical properties of the materials (e.g. structure, size, and chemical functions), by either stimulating or suppressing the immune response. However, a harmonized cutting-edge approach for the classification of these materials based not only on their physicochemical parameters but also their immune properties has been missing. The European Commission-funded G-IMMUNOMICS and CARBO-IMmap projects aimed to fill this gap, developing a functional pipeline for the qualitative and quantitative immune characterization of graphene, graphene-related materials (GRMs), and other CBMs. The goal was to open breakthrough perspectives for the definition of the immune profiles of these materials. Here, we summarize our methodological approach, key results, and the necessary multidisciplinary expertise ranging across various fields, from material chemistry to engineering, immunology, toxicology, and systems biology. G-IMMUNOMICS, as a partnering project of the Graphene Flagship, the largest scientific research initiative on graphene worldwide, also complemented the studies performed in the Flagship on health and environmental impact of GRMs. Finally, we present the nanoimmunity-by-design concept, developed within the projects, which can be readily applied to other 2D materials. Overall, the G-IMMUNOMICS and CARBO-IMmap projects have provided new insights on the immune impact of GRMs and CBMs, thus laying the foundation for their safe use and future translation in medicine.

Details

OriginalspracheEnglisch
Aufsatznummer034009
FachzeitschriftJPhys materials
Jahrgang3
Ausgabenummer3
PublikationsstatusVeröffentlicht - Juli 2020
Peer-Review-StatusJa

Schlagworte

Schlagwörter

  • Carbon nanotubes, Graphene, Nanomedicine, Nanosafety, Nanotoxicology, Single cell mass cytometry, Systems biology