Graphene and other 2D materials: A multidisciplinary analysis to uncover the hidden potential as cancer theranostics

Publikation: Beitrag in FachzeitschriftÜbersichtsartikel (Review)BeigetragenBegutachtung

Beitragende

  • Laura Fusco - , Università degli Studi di Trieste, Fondazione Istituto di Ricerca Pediatrica (IRP), Sidra Medical and Research Center (Autor:in)
  • Arianna Gazzi - , Università degli Studi di Trieste, Fondazione Istituto di Ricerca Pediatrica (IRP) (Autor:in)
  • Guotao Peng - , Karolinska Institutet (Autor:in)
  • Yuyoung Shin - , University of Manchester (Autor:in)
  • Sandra Vranic - , University of Manchester (Autor:in)
  • Davide Bedognetti - , Sidra Medical and Research Center (Autor:in)
  • Flavia Vitale - , University of Pennsylvania, VA Medical Center (Autor:in)
  • Acelya Yilmazer - , Ankara University (Autor:in)
  • Xinliang Feng - , Professur für Molekulare Funktionsmaterialien (cfaed) (Autor:in)
  • Bengt Fadeel - , Karolinska Institutet (Autor:in)
  • Cinzia Casiraghi - , University of Manchester (Autor:in)
  • Lucia Gemma Delogu - , Professur für Molekulare Funktionsmaterialien (cfaed), Fondazione Istituto di Ricerca Pediatrica (IRP), Università degli studi di Padova (Autor:in)

Abstract

Cancer represents one of the main causes of death in the world; hence the development of more specific approaches for its diagnosis and treatment is urgently needed in clinical practice. Here we aim at providing a comprehensive review on the use of 2-dimensional materials (2DMs) in cancer theranostics. In particular, we focus on graphene-related materials (GRMs), graphene hybrids, and graphdiyne (GDY), as well as other emerging 2DMs, such as MXene, tungsten disulfide (WS2), molybdenum disulfide (MoS2), hexagonal boron nitride (h-BN), black phosphorus (BP), silicene, antimonene (AM), germanene, biotite (black mica), metal organic frameworks (MOFs), and others. The results reported in the scientific literature in the last ten years (>200 papers) are dissected here with respect to the wide variety of combinations of imaging methodologies and therapeutic approaches, including drug/gene delivery, photothermal/photodynamic therapy, sonodynamic therapy, and immunotherapy. We provide a unique multidisciplinary approach in discussing the literature, which also includes a detailed section on the characterization methods used to analyze the material properties, highlighting the merits and limitations of the different approaches. The aim of this review is to show the strong potential of 2DMs for use as cancer theranostics, as well as to highlight issues that prevent the clinical translation of these materials. Overall, we hope to shed light on the hidden potential of the vast panorama of new and emerging 2DMs as clinical cancer theranostics.

Details

OriginalspracheEnglisch
Seiten (von - bis)5435-5488
Seitenumfang54
FachzeitschriftTheranostics
Jahrgang10
Ausgabenummer12
PublikationsstatusVeröffentlicht - 2020
Peer-Review-StatusJa

Externe IDs

PubMed 32373222

Schlagworte

Ziele für nachhaltige Entwicklung

Schlagwörter

  • 2D materials, Cancer theranostics, Future perspectives, Graphene, Nanomedicine