Glioblastoma multiforme: Emerging treatments and stratification markers beyond new drugs

Publikation: Beitrag in FachzeitschriftÜbersichtsartikel (Review)BeigetragenBegutachtung

Beitragende

Abstract

Glioblastoma multiforme (GBM) is the most common primary brain tumour in adults. The standard therapy for GBM ismaximal surgical resection followed by radiotherapy with concurrent and adjuvant temozolomide (TMZ). In spite of the extensive treatment, the disease is associated with poor clinical outcome. Further intensification of the standard treatment is limited by the infiltrating growth of the GBM in normal brain areas, the expected neurological toxicities with radiation doses .60Gy and the dose-limiting toxicities induced by systemic therapy. To improve the outcome of patients with GBM, alternative treatment modalities which add low or no additional toxicities to the standard treatment are needed. Many Phase II trials on new chemotherapeutics or targeted drugs have indicated potential efficacy but failed to improve the overall or progression-free survival in Phase III clinical trials. In this review, we will discuss contemporary issues related to recent technical developments and new metabolic strategies for patients with GBM including MR (spectroscopy) imaging, (amino acid) positron emission tomography (PET), amino acid PET, surgery, radiogenomics, particle therapy, radioimmunotherapy and diets.

Details

OriginalspracheEnglisch
Aufsatznummer20150354
Fachzeitschrift BJR : an international journal of radiology, radiation oncology and all related sciences
Jahrgang88
Ausgabenummer1053
PublikationsstatusVeröffentlicht - 1 Sept. 2015
Peer-Review-StatusJa

Externe IDs

researchoutputwizard legacy.publication#67714
researchoutputwizard legacy.publication#67979
Scopus 84941702873
PubMed 26159214

Schlagworte