Genomic analysis of sewage from 101 countries reveals global landscape of antimicrobial resistance

Publikation: Beitrag in FachzeitschriftForschungsartikelBeigetragenBegutachtung

Beitragende

  • Patrick Munk - , Technical University of Denmark (Autor:in)
  • Christian Brinch - , Technical University of Denmark (Autor:in)
  • Frederik Duus Møller - , Technical University of Denmark (Autor:in)
  • Thomas N. Petersen - , Technical University of Denmark (Autor:in)
  • Rene S. Hendriksen - , Technical University of Denmark (Autor:in)
  • Anne Mette Seyfarth - , Technical University of Denmark (Autor:in)
  • Jette S. Kjeldgaard - , Technical University of Denmark (Autor:in)
  • Christina Aaby Svendsen - , Technical University of Denmark (Autor:in)
  • Bram van Bunnik - , University of Edinburgh (Autor:in)
  • Fanny Berglund - , University of Gothenburg (Autor:in)
  • Global Sewage Surveillance Consortium - (Autor:in)
  • Institut für Klinische Pharmakologie
  • Professur für Limnologie (Gewässerökologie)
  • Albanian Institute of Public Health (IPH)
  • Universidad de Buenos Aires
  • State Government of Victoria
  • Charles Darwin University
  • Universität Kopenhagen
  • Canberra Hospital
  • ALS Water
  • Austrian Agency for Health and Food Safety GmbH
  • University of Dhaka
  • Bridgetown
  • Laboratoire Hospitalier Universitaire de Bruxelles (LHUB-ULB)
  • Aquafin, Belgium
  • Université d'Abomey-Calavi
  • Universidad Católica Boliviana
  • University of Banja Luka
  • Public Health Institute of the Republic of Srpska
  • Botswana International University of Science and Technology
  • Universidade Federal de Minas Gerais
  • Fundação Oswaldo Cruz
  • Instituto Tecnológico Vale
  • National Center of Infectious and Parasitic Diseases Bulgaria
  • Université de Ouagadougou
  • Institut Pasteur du Cambodge
  • Centre Pasteur du Cameroun
  • University of Regina
  • Institut national de la recherche scientifique
  • Université de N'Djamena
  • Universidad Andrés Bello
  • Technische Universität Dresden

Abstract

Antimicrobial resistance (AMR) is a major threat to global health. Understanding the emergence, evolution, and transmission of individual antibiotic resistance genes (ARGs) is essential to develop sustainable strategies combatting this threat. Here, we use metagenomic sequencing to analyse ARGs in 757 sewage samples from 243 cities in 101 countries, collected from 2016 to 2019. We find regional patterns in resistomes, and these differ between subsets corresponding to drug classes and are partly driven by taxonomic variation. The genetic environments of 49 common ARGs are highly diverse, with most common ARGs carried by multiple distinct genomic contexts globally and sometimes on plasmids. Analysis of flanking sequence revealed ARG-specific patterns of dispersal limitation and global transmission. Our data furthermore suggest certain geographies are more prone to transmission events and should receive additional attention.

Details

OriginalspracheEnglisch
Aufsatznummer7251
FachzeitschriftNature communications
Jahrgang13
Ausgabenummer1
PublikationsstatusVeröffentlicht - Dez. 2022
Peer-Review-StatusJa

Externe IDs

PubMed 36456547
ORCID /0000-0003-1054-8080/work/142657174
ORCID /0000-0002-9301-1803/work/161409824