Genetic influence on neurogenesis in the dentate gyrus of adult mice

Publikation: Beitrag in FachzeitschriftForschungsartikelBeigetragenBegutachtung

Beitragende

Abstract

To address genetic influences on hippocampal neurogenesis in adult mice, we compared C57BL/6, BALB/c, CD1(ICR), and 129Sv/J mice to examine proliferation, survival, and differentiation of newborn cells in the dentate gyrus. Proliferation was highest in C57BL/6; the survival rate of newborn cells was highest in CD1. In all strains ≃60% of surviving newborn cells had a neuronal phenotype, but 129/SvJ produced more astrocytes. Over 6 days C57BL/6 produced 0.36% of their total granule cell number of 239,000 as new neurons, BALB/c 0.30% of 242,000. CD1 (ICR) 0.32% of 351,000, and 129/SvJ 0.16% of 280,000. These results show that different aspects of adult hippocampal neurogenesis are differentially influenced by the genetic background.

Details

OriginalspracheEnglisch
Seiten (von - bis)10409-10414
Seitenumfang6
FachzeitschriftProceedings of the National Academy of Sciences of the United States of America
Jahrgang94
Ausgabenummer19
PublikationsstatusVeröffentlicht - 16 Sept. 1997
Peer-Review-StatusJa

Externe IDs

PubMed 9294224
ORCID /0000-0002-5304-4061/work/161408172

Schlagworte

ASJC Scopus Sachgebiete