Gene-environment interactions in the influence of maternal education on adolescent neurodevelopment using ABCD study

Publikation: Beitrag in FachzeitschriftForschungsartikelBeigetragenBegutachtung

Beitragende

  • IMAGEN Consortium - (Autor:in)
  • Klinik und Poliklinik für Psychiatrie und Psychotherapie
  • Technische Universität Dresden
  • Fudan University
  • Universität Heidelberg
  • King's College London (KCL)
  • Trinity College Dublin
  • Universität Mannheim
  • Université Paris-Saclay
  • University of Vermont
  • University of Nottingham
  • Berliner Institut für Gesundheitsforschung in der Charité
  • Physikalisch-Technische Bundesanstalt
  • École normale supérieure Paris-Saclay
  • Sorbonne Université
  • EPS Barthélémy Durand
  • Universitätsklinikum Schleswig-Holstein Campus Kiel
  • Georg-August-Universität Göttingen
  • Universität Hamburg
  • Charité – Universitätsmedizin Berlin
  • University of Warwick

Abstract

Maternal education was strongly correlated with adolescent brain morphology, cognitive performances, and mental health. However, the molecular basis for the effects of maternal education on the structural neurodevelopment remains unknown. Here, we conducted gene-environment-wide interaction study using the Adolescent Brain Cognitive Development cohort. Seven genomic loci with significant gene-environment interactions (G×E) on regional gray matter volumes were identified, with enriched biological functions related to metabolic process, inflammatory process, and synaptic plasticity. Additionally, genetic overlapping results with behavioral and disease-related phenotypes indicated shared biological mechanism between maternal education modified neurodevelopment and related behavioral traits. Finally, by decomposing the multidimensional components of maternal education, we found that socioeconomic status, rather than family environment, played a more important role in modifying the genetic effects on neurodevelopment. In summary, our study provided analytical evidence for G×E effects regarding adolescent neurodevelopment and explored potential biological mechanisms as well as social mechanisms through which maternal education could modify the genetic effects on regional brain development.

Details

OriginalspracheEnglisch
Aufsatznummereadp3751
Seitenumfang18
FachzeitschriftScience advances
Jahrgang10
Ausgabenummer46
PublikationsstatusVeröffentlicht - 15 Nov. 2024
Peer-Review-StatusJa

Externe IDs

PubMedCentral PMC11567010
Scopus 85209702348
ORCID /0000-0001-5398-5569/work/175768374

Schlagworte

Schlagwörter

  • Humans, Gene-Environment Interaction, Adolescent, Female, Brain/growth & development, Male, Educational Status, Genome-Wide Association Study, Cognition/physiology, Polymorphism, Single Nucleotide, Adolescent Development