Gene mention normalization and interaction extraction with context models and sentence motifs

Publikation: Beitrag in FachzeitschriftForschungsartikelBeigetragenBegutachtung

Beitragende

  • Jörg Hakenberg - , Biotechnologisches Zentrum (BIOTEC) (Autor:in)
  • Conrad Plake - (Autor:in)
  • Loic Royer - (Autor:in)
  • Hendrik Strobelt - (Autor:in)
  • Ulf Leser - (Autor:in)
  • Michael Schroeder - , Professur für Bioinformatik (Autor:in)

Abstract

BACKGROUND: The goal of text mining is to make the information conveyed in scientific publications accessible to structured search and automatic analysis. Two important subtasks of text mining are entity mention normalization - to identify biomedical objects in text - and extraction of qualified relationships between those objects. We describe a method for identifying genes and relationships between proteins.

RESULTS: We present solutions to gene mention normalization and extraction of protein-protein interactions. For the first task, we identify genes by using background knowledge on each gene, namely annotations related to function, location, disease, and so on. Our approach currently achieves an f-measure of 86.4% on the BioCreative II gene normalization data. For the extraction of protein-protein interactions, we pursue an approach that builds on classical sequence analysis: motifs derived from multiple sequence alignments. The method achieves an f-measure of 24.4% (micro-average) in the BioCreative II interaction pair subtask.

CONCLUSION: For gene mention normalization, our approach outperforms strategies that utilize only the matching of genes names against dictionaries, without invoking further knowledge on each gene. Motifs derived from alignments of sentences are successful at identifying protein interactions in text; the approach we present in this report is fully automated and performs similarly to systems that require human intervention at one or more stages.

AVAILABILITY: Our methods for gene, protein, and species identification, and extraction of protein-protein are available as part of the BioCreative Meta Services (BCMS), see http://bcms.bioinfo.cnio.es/.

Details

OriginalspracheEnglisch
AufsatznummerS14
FachzeitschriftGenome biology : biology for the post-genomic era
Jahrgang9
AusgabenummerSuppl 2
PublikationsstatusVeröffentlicht - 2008
Peer-Review-StatusJa

Externe IDs

PubMedCentral PMC2559985
ORCID /0000-0003-2848-6949/work/141543398
Scopus 49549095524

Schlagworte

Ziele für nachhaltige Entwicklung

Schlagwörter

  • Animals, Drosophila, Genes, Information Storage and Retrieval, Mice, Models, Biological, Protein Interaction Mapping, Semantics, Sequence Alignment

Bibliotheksschlagworte