From cell intercalation to flow, the importance of T1 transitions

Publikation: Beitrag in FachzeitschriftForschungsartikelBeigetragenBegutachtung

Beitragende

Abstract

T1 transitions, also called cell intercalations, are important sources of fluidization of epithelial cell monolayers. We use a multiphase field model to quantify this tissue fluidization in terms of the relative dispersion of cells and characterize the T1 flow profile. We show that the ensemble-averaged flow profile of a T1 transition has a saddle-point pattern accompanied by a localized burst in cell speed. Although the temporal evolution of the relative dispersion of cells depends on specific model details, the different dispersion curves collapse robustly onto a linear function of the number of T1 transitions, implying an important connection between T1 transitions and mixing in dense systems.

Details

OriginalspracheEnglisch
Aufsatznummer033176
Seitenumfang9
FachzeitschriftPhysical Review Research
Jahrgang6 (2024)
Ausgabenummer3
PublikationsstatusVeröffentlicht - 15 Aug. 2024
Peer-Review-StatusJa

Schlagworte

ASJC Scopus Sachgebiete