First-Line Immune Combination Therapies for Nonclear Cell Versus Clear Cell Metastatic Renal Cell Carcinoma: Real-World Multicenter Data From Germany

Publikation: Beitrag in FachzeitschriftForschungsartikelBeigetragenBegutachtung

Beitragende

  • Cristina Cano Garcia - , Universitätsklinikum Frankfurt (Autor:in)
  • Benedikt Hoeh - , Universitätsklinikum Frankfurt (Autor:in)
  • Subhajit Mandal - , Philipps-Universität Marburg (Autor:in)
  • Severine Banek - , Universitätsklinikum Frankfurt (Autor:in)
  • Niklas Klümper - , Universität Bonn (Autor:in)
  • Philipp Schmucker - , Julius-Maximilians-Universität Würzburg (Autor:in)
  • Oliver Hahn - , Julius-Maximilians-Universität Würzburg (Autor:in)
  • Angelika Mattigk - , Universität Ulm (Autor:in)
  • Jörg Ellinger - , Universität Bonn (Autor:in)
  • Alexander Cox - , Universität Bonn (Autor:in)
  • Philippe Becker - , Universität des Saarlandes (Autor:in)
  • Philip Zeuschner - , Universität des Saarlandes (Autor:in)
  • Friedemann Zengerling - , Universität Ulm (Autor:in)
  • Kati Erdmann - , Klinik und Poliklinik für Urologie (Autor:in)
  • Bjoern Thorben Buerk - , Klinik und Poliklinik für Urologie (Autor:in)
  • Charis Kalogirou - , Julius-Maximilians-Universität Würzburg (Autor:in)
  • Luka Flegar - , Philipps-Universität Marburg (Autor:in)

Abstract

Introduction: The aim was to compare treatment outcomes of clear cell metastatic renal cell carcinoma (ccmRCC) versus non-ccmRCC (nccmRCC) patients who received first-line immune combination therapies. Materials and Methods: Within our retrospective multi-institutional consecutive database of eight tertiary-care centers, we identified mRCC patients treated with first-line immune combination therapies between 11/2017 and 12/2022. Using log-rank analysis and multivariable Cox regression, we tested for differences in overall survival (OS) and progression-free survival (PFS) of nccmRCC versus ccmRCC patients. Covariables consisted of age at diagnosis, sex, International Metastatic Renal Cell Carcinoma Database Consortium risk groups, Eastern Cooperative Oncology Group status, and sarcomatoid feature. Results: Of 289 study patients, 39 (13%) patients harbored nccmRCC. Median OS was 37 months versus not reached for ccmRCC versus nccmRCC patients (P = .6). Median PFS was 13 versus 15 months (P = .9). Multivariable Cox regression models did not identify nccmRCC as an independent predictor of higher overall mortality in mRCC patients (hazard ratio [HR]: 1.23; P = .6) or a higher progression rate (HR: 1.0; P = 1.0). Conclusion: In our real-world multi-institutional study, no differences in OS and PFS between ccmRCC and nccmRCC patients receiving first-line immune combination treatment were observed, even after adjustment for important patient and tumor characteristics. More prospective trials in nccmRCC patients are needed.

Details

OriginalspracheEnglisch
Aufsatznummer102112
Seiten (von - bis)1-11
Seitenumfang11
FachzeitschriftClinical genitourinary cancer
Jahrgang22
Ausgabenummer4
PublikationsstatusVeröffentlicht - Aug. 2024
Peer-Review-StatusJa

Externe IDs

PubMed 38825563
ORCID /0000-0003-3717-3637/work/173516991

Schlagworte

Ziele für nachhaltige Entwicklung

ASJC Scopus Sachgebiete

Schlagwörter

  • Checkpoint inhibition, First-line therapy, Immunotherapy, Metastatic renal cell carcinoma, Nonclear cell renal cell cancer