First Synthesis, Confirmation of Stereochemistry, and Cytotoxic Activity of Oxyfungiformin

Publikation: Beitrag in FachzeitschriftForschungsartikelBeigetragenBegutachtung

Beitragende

Abstract

The relative configuration of the marine sesquiterpenoid oxyfungiformin, isolated from the soft coral Capnella fungiformis, was confirmed by synthesis using the natural product guaiol as chiral precursor. The absolute configuration of oxyfungiformin could be assigned by combination of X-ray diffraction and comparison of the values for the specific optical rotation. Oxyfungiformin and a diastereoisomer showed cytotoxic activity in cells originating from cancers of the lung, breast, and cervix.

Details

OriginalspracheEnglisch
Aufsatznummere202200809
FachzeitschriftEuropean journal of organic chemistry: EurJOC
Jahrgang2022
Ausgabenummer36
PublikationsstatusVeröffentlicht - 27 Sept. 2022
Peer-Review-StatusJa

Externe IDs

Scopus 85138860118
ORCID /0000-0002-5381-0547/work/161889064
ORCID /0000-0003-3383-9518/work/161891423
ORCID /0000-0001-5684-629X/work/161892079

Schlagworte

Ziele für nachhaltige Entwicklung