Exploratory study of ultraviolet B (UVB) radiation and age of onset of bipolar disorder
Publikation: Beitrag in Fachzeitschrift › Forschungsartikel › Beigetragen › Begutachtung
Beitragende
Abstract
BACKGROUND: Sunlight contains ultraviolet B (UVB) radiation that triggers the production of vitamin D by skin. Vitamin D has widespread effects on brain function in both developing and adult brains. However, many people live at latitudes (about > 40 N or S) that do not receive enough UVB in winter to produce vitamin D. This exploratory study investigated the association between the age of onset of bipolar I disorder and the threshold for UVB sufficient for vitamin D production in a large global sample.
METHODS: Data for 6972 patients with bipolar I disorder were obtained at 75 collection sites in 41 countries in both hemispheres. The best model to assess the relation between the threshold for UVB sufficient for vitamin D production and age of onset included 1 or more months below the threshold, family history of mood disorders, and birth cohort. All coefficients estimated at P ≤ 0.001.
RESULTS: The 6972 patients had an onset in 582 locations in 70 countries, with a mean age of onset of 25.6 years. Of the onset locations, 34.0% had at least 1 month below the threshold for UVB sufficient for vitamin D production. The age of onset at locations with 1 or more months of less than or equal to the threshold for UVB was 1.66 years younger.
CONCLUSION: UVB and vitamin D may have an important influence on the development of bipolar disorder. Study limitations included a lack of data on patient vitamin D levels, lifestyles, or supplement use. More study of the impacts of UVB and vitamin D in bipolar disorder is needed to evaluate this supposition.
Details
Originalsprache | Englisch |
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Aufsatznummer | 22 |
Seitenumfang | 9 |
Fachzeitschrift | International journal of bipolar disorders |
Jahrgang | 11 |
Publikationsstatus | Veröffentlicht - 22 Juni 2023 |
Peer-Review-Status | Ja |
Externe IDs
ORCID | /0000-0003-4286-5830/work/148143974 |
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ORCID | /0000-0002-3974-7115/work/148144900 |
ORCID | /0000-0002-2666-859X/work/148145079 |
ORCID | /0000-0003-4163-9014/work/148145669 |
ORCID | /0000-0002-3415-5583/work/150329715 |
PubMed | 37347392 |
PubMedCentral | PMC10287592 |