Exploratory study of ultraviolet B (UVB) radiation and age of onset of bipolar disorder

Publikation: Beitrag in FachzeitschriftForschungsartikelBeigetragenBegutachtung

Beitragende

  • Michael Bauer - , Klinik und Poliklinik für Psychiatrie und Psychotherapie (Autor:in)
  • Tasha Glenn - , ChronoRecord Association (Autor:in)
  • Eric D Achtyes - , Michigan State University College of Human Medicine (MSUCHM) (Autor:in)
  • Martin Alda - , Dalhousie University (Autor:in)
  • Esen Agaoglu - , Hacettepe University Faculty of Medicine (Autor:in)
  • Kürsat Altınbaş - , Selcuk University Faculty of Medicine (Autor:in)
  • Ole A Andreassen - , University of Oslo (Autor:in)
  • Elias Angelopoulos - , National and Capodistrian University of Athens (Autor:in)
  • Raffaella Ardau - , Università degli Studi di Cagliari (Autor:in)
  • Memduha Aydin - , Selcuk University Faculty of Medicine (Autor:in)
  • Yavuz Ayhan - , Hacettepe University Faculty of Medicine (Autor:in)
  • Christopher Baethge - , University of Cologne Medical School (Autor:in)
  • Rita Bauer - , Klinik und Poliklinik für Psychiatrie und Psychotherapie (Autor:in)
  • Bernhard T Baune - , Westfälische Wilhelms-Universität Münster (Autor:in)
  • Ceylan Balaban - , Universitätsklinikum Frankfurt (Autor:in)
  • Claudia Becerra-Palars - , National Institute of Psychiatry '"Ramón de la Fuente Muñiz" (Autor:in)
  • Aniruddh P Behere - , Michigan State University (Autor:in)
  • Prakash B Behere - , Datta Meghe Institute of Medical Sciences (Autor:in)
  • Habte Belete - , Bahir Dar University (Autor:in)
  • Tilahun Belete - , Bahir Dar University (Autor:in)
  • Gabriel Okawa Belizario - , University of São Paulo Medical School (Autor:in)
  • Frank Bellivier - , Département de Psychiatrie et de Médecine Addictologique (Autor:in)
  • Robert H Belmaker - , Ben-Gurion University of the Negev (Autor:in)
  • Francesco Benedetti - , Vita-Salute San Raffaele University (Autor:in)
  • Michael Berk - , Deakin University (Autor:in)
  • Yuly Bersudsky - , Ben-Gurion University of the Negev (Autor:in)
  • Şule Bicakci - , Hacettepe University Faculty of Medicine (Autor:in)
  • Harriet Birabwa-Oketcho - , Butabika Hospital (Autor:in)
  • Thomas D Bjella - , University of Oslo (Autor:in)
  • Conan Brady - , St Patrick's University Hospital (Autor:in)
  • Jorge Cabrera - , Dr. Jose Horwitz Psychiatric Institute (Autor:in)
  • Marco Cappucciati - , Department of Mental Health and Substance Abuse (Autor:in)
  • Angela Marianne Paredes Castro - , Deakin University (Autor:in)
  • Wei-Ling Chen - , Veterans General Hospital-Taichung Taiwan (Autor:in)
  • Eric Y W Cheung - , Private practice (Autor:in)
  • Silvia Chiesa - , Department of Mental Health and Substance Abuse (Autor:in)
  • Marie Crowe - , University of Otago (Autor:in)
  • Alessandro Cuomo - , University of Siena Medical Center (AOUS) (Autor:in)
  • Sara Dallaspezia - , Scientific Institute Ospedale San Raffaele (Autor:in)
  • Maria Del Zompo - , Università degli Studi di Cagliari (Autor:in)
  • Pratikkumar Desai - , Michigan State University College of Human Medicine (MSUCHM) (Autor:in)
  • Seetal Dodd - , Deakin University (Autor:in)
  • Bruno Etain - , Département de Psychiatrie et de Médecine Addictologique (Autor:in)
  • Andrea Fagiolini - , University of Siena Medical Center (AOUS) (Autor:in)
  • Frederike T Fellendorf - , Medizinische Universität Graz (Autor:in)
  • Ewa Ferensztajn-Rochowiak - , University of Medical Sciences Poznan (Autor:in)
  • Jess G Fiedorowicz - , University of Ottawa and the Ottawa Hospital Research Institute (Autor:in)
  • Kostas N Fountoulakis - , Aristotle University of Thessaloniki (Autor:in)
  • Mark A Frye - , Mayo Clinic Depression Center (Autor:in)
  • Pierre A Geoffroy - , Département de Psychiatrie et d'addictologie (Autor:in)
  • Michael J Gitlin - , University of California at Los Angeles (Autor:in)
  • Ana Gonzalez-Pinto - , University Hospital of Alava (Autor:in)
  • John F Gottlieb - , Northwestern University (Autor:in)
  • Paul Grof - , University of Toronto (Autor:in)
  • Bartholomeus C M Haarman - , University of Groningen (Autor:in)
  • Hirohiko Harima - , Tokyo Metropolitan Matsuzawa Hospital (Autor:in)
  • Mathias Hasse-Sousa - , Amsterdam University Medical Centers (UMC) (Autor:in)
  • Chantal Henry - , Amsterdam University Medical Centers (UMC) (Autor:in)
  • Lone Hoffding - , University of Southern Denmark (Autor:in)
  • Josselin Houenou - , Mondor Univ Hospitals (Autor:in)
  • Massimiliano Imbesi - , Department of Mental Health and Substance Abuse (Autor:in)
  • Erkki T Isometsä - , Universitätsklinikum Helsinki (Autor:in)
  • Maja Ivkovic - , Clinical Center of Serbia (Autor:in)
  • Sven Janno - , University of Tartu (Autor:in)
  • Simon Johnsen - , Aalborg University (Autor:in)
  • Flávio Kapczinski - , Amsterdam University Medical Centers (UMC) (Autor:in)
  • Gregory N Karakatsoulis - , Aristotle University of Thessaloniki (Autor:in)
  • Mathias Kardell - , University of Gothenburg (Autor:in)
  • Lars Vedel Kessing - , Psychiatric Center Copenhagen (Autor:in)
  • Seong Jae Kim - , Chosun University School of Medicine (Autor:in)
  • Barbara König - , BIPOLAR Zentrum Wiener Neustadt (Autor:in)
  • Timur L Kot - , Khanty-Mansiysk Clinical Psychoneurological Hospital (Autor:in)
  • Michael Koval - , Michigan State University (Autor:in)
  • Mauricio Kunz - , Amsterdam University Medical Centers (UMC) (Autor:in)
  • Beny Lafer - , University of São Paulo Medical School (Autor:in)
  • Mikael Landén - , University of Gothenburg (Autor:in)
  • Erik R Larsen - , University of Southern Denmark (Autor:in)
  • Melanie Lenger - , Medizinische Universität Graz (Autor:in)
  • Rasmus W Licht - , Aalborg University (Autor:in)
  • Carlos Lopez-Jaramillo - , Hospital Universitario San Vicente Fundación (Autor:in)
  • Alan MacKenzie - , University of Glasgow (Autor:in)
  • Helle Østergaard Madsen - , Copenhagen University Hospitals (Autor:in)
  • Simone Alberte Kongstad A Madsen - , Aalborg University (Autor:in)
  • Jayant Mahadevan - , National Institute of Mental Health and Neuro Sciences (NIMHANS) (Autor:in)
  • Agustine Mahardika - , University of Mataram (Autor:in)
  • Mirko Manchia - , Dalhousie University (Autor:in)
  • Wendy Marsh - , University of Massachusetts Medical School (Autor:in)
  • Monica Martinez-Cengotitabengoa - , University of the Basque Country (Autor:in)
  • Julia Martini - , Klinik und Poliklinik für Psychiatrie und Psychotherapie (Autor:in)
  • Klaus Martiny - , Copenhagen University Hospitals (Autor:in)
  • Yuki Mashima - , Keio University School of Medicine (Autor:in)
  • Declan M McLoughlin - , St Patrick's University Hospital (Autor:in)
  • Ybe Meesters - , University of Groningen (Autor:in)
  • Ingrid Melle - , University of Oslo (Autor:in)
  • Fátima Meza-Urzúa - , Klinik und Poliklinik für Kinder- und Jugendmedizin (Autor:in)
  • Pavol Mikolas - , Klinik und Poliklinik für Psychiatrie und Psychotherapie (Autor:in)
  • Yee Ming Mok - , Singapore Institute of Mental Health (Autor:in)
  • Scott Monteith - , Michigan State University College of Human Medicine (MSUCHM) (Autor:in)
  • Muthukumaran Moorthy - , National Institute of Mental Health and Neuro Sciences (NIMHANS) (Autor:in)
  • Gunnar Morken - , Norwegian University of Science and Technology (Autor:in)
  • Enrica Mosca - , Università degli Studi di Cagliari (Autor:in)
  • Anton A Mozzhegorov - , Soviet Psychoneurological Hospital (Autor:in)
  • Rodrigo Munoz - , University of California at San Diego (Autor:in)
  • Starlin V Mythri - , Makunda Christian Leprosy and General Hospital (Autor:in)
  • Fethi Nacef - , Université de Tunis El Manar (Autor:in)
  • Ravi K Nadella - , National Institute of Mental Health and Neuro Sciences (NIMHANS) (Autor:in)
  • Takako Nakanotani - , Tokyo Metropolitan Hiroo Hospital (Autor:in)
  • René Ernst Nielsen - , Aalborg University (Autor:in)
  • Claire O'Donovan - , Dalhousie University (Autor:in)
  • Adel Omrani - , Tunisian Bipolar Forum (Autor:in)
  • Yamima Osher - , Ben-Gurion University of the Negev (Autor:in)
  • Uta Ouali - , Université de Tunis El Manar (Autor:in)
  • Maja Pantovic-Stefanovic - , Clinical Center of Serbia (Autor:in)
  • Pornjira Pariwatcharakul - , Mahidol University (Autor:in)
  • Joanne Petite - , Dalhousie University (Autor:in)
  • Johannes Petzold - , Klinik und Poliklinik für Psychiatrie und Psychotherapie (Autor:in)
  • Andrea Pfennig - , Klinik und Poliklinik für Psychiatrie und Psychotherapie (Autor:in)
  • Yolanda Pica Ruiz - , Hospital "Ángeles del Pedregal" (Autor:in)
  • Marco Pinna - , Università degli Studi di Cagliari (Autor:in)
  • Maurizio Pompili - , University of Rome La Sapienza (Autor:in)
  • Richard J Porter - , University of Otago (Autor:in)
  • Danilo Quiroz - , Diego Portales University (Autor:in)
  • Francisco Diego Rabelo-da-Ponte - , University of Central Lancashire (Autor:in)
  • Raj Ramesar - , University of Cape Town (Autor:in)
  • Natalie Rasgon - , Stanford Medicine (Autor:in)
  • Woraphat Ratta-Apha - , Mahidol University (Autor:in)
  • Michaela Ratzenhofer - , Medizinische Universität Graz (Autor:in)
  • Maria Redahan - , St Patrick's University Hospital (Autor:in)
  • M S Reddy - , Asha Hospital (Autor:in)
  • Andreas Reif - , Universitätsklinikum Frankfurt (Autor:in)
  • Eva Z Reininghaus - , Medizinische Universität Graz (Autor:in)
  • Jenny Gringer Richards - , The University of Iowa (Autor:in)
  • Philipp Ritter - , Klinik und Poliklinik für Psychiatrie und Psychotherapie (Autor:in)
  • Janusz K Rybakowski - , University of Medical Sciences Poznan (Autor:in)
  • Leela Sathyaputri - , The University of Iowa (Autor:in)
  • Angela M Scippa - , Federal University of Bahia (Autor:in)
  • Christian Simhandl - , BIPOLAR Zentrum Wiener Neustadt (Autor:in)
  • Daniel Smith - , University of Edinburgh (Autor:in)
  • José Smith - , Bay Area Environmental Research Institute (Autor:in)
  • Paul W Stackhouse - , NASA Langley Research Center (Autor:in)
  • Dan J Stein - , University of Cape Town (Autor:in)
  • Kellen Stilwell - , Michigan State University College of Human Medicine (MSUCHM) (Autor:in)
  • Sergio Strejilevich - , Bay Area Environmental Research Institute (Autor:in)
  • Kuan-Pin Su - , China Medical University (Autor:in)
  • Mythily Subramaniam - , Singapore Institute of Mental Health (Autor:in)
  • Ahmad Hatim Sulaiman - , University of Malaya (Autor:in)
  • Kirsi Suominen - , Department of Social Services and Health Care (Autor:in)
  • Andi J Tanra - , Hasanuddin University (Autor:in)
  • Yoshitaka Tatebayashi - , Tokyo Metropolitan Hiroo Hospital (Autor:in)
  • Wen Lin Teh - , Singapore Institute of Mental Health (Autor:in)
  • Leonardo Tondo - , McLean Hospital-Harvard Medical School (Autor:in)
  • Carla Torrent - , University of Barcelona (Autor:in)
  • Daniel Tuinstra - , Michigan State University College of Human Medicine (MSUCHM) (Autor:in)
  • Takahito Uchida - , Keio University School of Medicine (Autor:in)
  • Arne E Vaaler - , Norwegian University of Science and Technology (Autor:in)
  • Eduard Vieta - , University of Barcelona (Autor:in)
  • Biju Viswanath - , National Institute of Mental Health and Neuro Sciences (NIMHANS) (Autor:in)
  • Maria Yoldi-Negrete - , Subdirección de Investigaciones Clínicas (Autor:in)
  • Oguz Kaan Yalcinkaya - , Hacettepe University Faculty of Medicine (Autor:in)
  • Allan H Young - , King's College London (KCL) (Autor:in)
  • Yosra Zgueb - , Université de Tunis El Manar (Autor:in)
  • Peter C Whybrow - , University of California at Los Angeles (Autor:in)

Abstract

BACKGROUND: Sunlight contains ultraviolet B (UVB) radiation that triggers the production of vitamin D by skin. Vitamin D has widespread effects on brain function in both developing and adult brains. However, many people live at latitudes (about > 40 N or S) that do not receive enough UVB in winter to produce vitamin D. This exploratory study investigated the association between the age of onset of bipolar I disorder and the threshold for UVB sufficient for vitamin D production in a large global sample.

METHODS: Data for 6972 patients with bipolar I disorder were obtained at 75 collection sites in 41 countries in both hemispheres. The best model to assess the relation between the threshold for UVB sufficient for vitamin D production and age of onset included 1 or more months below the threshold, family history of mood disorders, and birth cohort. All coefficients estimated at P ≤ 0.001.

RESULTS: The 6972 patients had an onset in 582 locations in 70 countries, with a mean age of onset of 25.6 years. Of the onset locations, 34.0% had at least 1 month below the threshold for UVB sufficient for vitamin D production. The age of onset at locations with 1 or more months of less than or equal to the threshold for UVB was 1.66 years younger.

CONCLUSION: UVB and vitamin D may have an important influence on the development of bipolar disorder. Study limitations included a lack of data on patient vitamin D levels, lifestyles, or supplement use. More study of the impacts of UVB and vitamin D in bipolar disorder is needed to evaluate this supposition.

Details

OriginalspracheEnglisch
Aufsatznummer22
Seiten (von - bis)1-9
Seitenumfang9
FachzeitschriftInternational journal of bipolar disorders
Jahrgang11
Ausgabenummer2023
PublikationsstatusVeröffentlicht - Dez. 2023
Peer-Review-StatusJa

Externe IDs

ORCID /0000-0003-4286-5830/work/148143974
ORCID /0000-0002-3974-7115/work/148144900
ORCID /0000-0002-2666-859X/work/148145079
ORCID /0000-0003-4163-9014/work/148145669
ORCID /0000-0002-3415-5583/work/150329715
PubMed 37347392
PubMedCentral PMC10287592

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