Microreactors intensify chemical processes due to improved flow regimes, mass and heat transfer. In the present study, the effect of the volume flow rate on reactor performance in different reactors (the T-shaped reactor, the interdigital microreactor and the chicane microreactor) was investigated. For this purpose, the saponification reaction in these reactor systems was considered. Experimental results were verified using the obtained kinetic model. The reactor system with a Tshaped reactor shows good performance only at high flow rates, while the experimental setups with the interdigital and the chicane microreactors yield good performance throughout the whole range of volume flow rates. However, microreactors exhibit a higher pressure drop, indicating higher mechanical flow energy consumption than seen using a T-shaped reactor.