Every islet matters: improving the impact of human islet research

Publikation: Beitrag in FachzeitschriftForschungsartikelBeigetragenBegutachtung


  • Anna L. Gloyn - , Stanford University (Autor:in)
  • Mark Ibberson - , Swiss Institute of Bioinformatics (Autor:in)
  • Piero Marchetti - , University of Pisa (Autor:in)
  • Alvin C. Powers - , Vanderbilt University, VA Medical Center (Autor:in)
  • Patrik Rorsman - , University of Oxford, University of Gothenburg (Autor:in)
  • Maike Sander - , University of California at San Diego (Autor:in)
  • Michele Solimena - , Molekulare Diabetologie, Universitätsklinikum Carl Gustav Carus Dresden, Technische Universität Dresden (Autor:in)


Detailed characterization of human pancreatic islets is key to elucidating the pathophysiology of all forms of diabetes, especially type 2 diabetes. However, access to human pancreatic islets is limited. Pancreatic tissue for islet retrieval can be obtained from brain-dead organ donors or from individuals undergoing pancreatectomy, often referred to as ‘living donors’. Different protocols for human islet procurement can substantially impact islet function. This variability, coupled with heterogeneity between individuals and islets, results in analytical challenges to separate genuine disease pathology or differences between human donors from experimental noise. There are currently no international guidelines for human donor phenotyping, islet procurement and functional characterization. This lack of standardization means that substantial investments from multiple international efforts towards improved understanding of diabetes pathology cannot be fully leveraged. In this Perspective, we overview the status of the field of human islet research, highlight the challenges and propose actions that could accelerate research progress and increase understanding of type 2 diabetes to slow its pandemic spreading.


Seiten (von - bis)970-977
FachzeitschriftNature metabolism
PublikationsstatusVeröffentlicht - Aug. 2022

Externe IDs

PubMed 35953581